Multiple myeloma macrophages: pivotal players in the tumor microenvironment.
Multiple myeloma macrophages: pivotal players in the tumor microenvironment.
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DOI：
10.1155/2013/183602
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发表时间：
2013
影响因子：
--
通讯作者：
Vacca A
中科院分区：
文献类型：
--
作者：
Berardi S;Ria R;Reale A;De Luisi A;Catacchio I;Moschetta M;Vacca A
肿瘤微环境通过提供生存信号、分泌生长因子和促血管生成因子，对多发性骨髓瘤(MM)的生长、进展和耐药起着至关重要的作用。本文研究了巨噬细胞在MM骨髓微环境中的重要性，称为MM相关巨噬细胞，作为支持肿瘤浆细胞的潜在利基成分。这些巨噬细胞来自外周血单核细胞，这些单核细胞被募集到肿瘤中。巨噬细胞被MM浆细胞和间充质基质细胞激活后，可以释放促进浆细胞生长和存活的生长因子、蛋白水解酶、细胞因子和炎症介质。巨噬细胞通过血管生成、生长和耐药等多种机制促进肿瘤进展。事实上，这些巨噬细胞对于通过血管生成拟态诱导血管生成反应是必不可少的，这种能力与浆细胞肿瘤的进展同步进行。资料表明，巨噬细胞在MM患者的生物学和生存中起着重要作用，可能成为MM抗血管治疗的靶点。
Tumor microenvironment is essential for multiple myeloma (MM) growth, progression, and drug resistance through provision of survival signals and secretion of growth and proangiogenic factors. This paper examines the importance of macrophages within MM bone marrow (BM) microenvironment, referred to as MM-associated macrophages, as a potential niche component that supports tumor plasma cells. These macrophages are derived from peripheral blood monocytes recruited into the tumor. Upon activation by MM plasma cells and mesenchymal stromal cells, macrophages can release growth factors, proteolytic enzymes, cytokines, and inflammatory mediators that promote plasma cell growth and survival. Macrophages promote tumor progression through several mechanisms including angiogenesis, growth, and drug resistance. Indeed, these macrophages are essential for the induction of an angiogenic response through vasculogenic mimicry, and this ability proceeds in step with progression of the plasma cell tumors. Data suggest that macrophages play an important role in the biology and survival of patients with MM, and they may be a target for the MM antivascular management.