Childhood air pollutant exposure and carotid artery intima-media thickness in young adults.
Childhood air pollutant exposure and carotid artery intima-media thickness in young adults.
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儿童空气污染物暴露和颈动脉内膜膜厚度的年轻人。
DOI：
10.1161/circulationaha.112.096164
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发表时间：
2012-09-25
期刊：
影响因子：
37.8
通讯作者：
Avol E
中科院分区：
文献类型：
--
作者：
Breton CV;Wang X;Mack WJ;Berhane K;Lopez M;Islam TS;Feng M;Lurmann F;McConnell R;Hodis HN;Künzli N;Avol E
暴露于环境空气污染物会增加成人心血管健康结果的风险。儿童空气污染物暴露对心血管健康的影响尚未得到彻底评估。青年测试反应研究由 2007 年至 2009 年从南加州大学招募的 861 名大学生组成。参与者参加了一项研究访问，期间评估了血压、心率和颈动脉内膜中层厚度（CIMT）。自填问卷收集有关健康和社会人口特征的信息，并抽取 12 小时空腹血样进行血脂和生物标志物分析。住宅地址经过地理编码，并根据来自美国环境保护局空气质量系统 (AQS) 数据库的数据来分配累积空气污染物暴露估计值。使用线性回归分析评估 CIMT 和空气污染物之间的关联。平均 CIMT 为 603 μm (± 54 SD)。儿童（0-5 岁）或小学（6-12 岁）O3 暴露增加 2 个标准差 (SD) 分别与 CIMT 升高 7.8 μm (95% CI -0.3, 15.9) 或 10.1 μm (95% CI 1.8, 18.5) 相关。终生接触 O3 显示出类似但不显着的关联。尽管对 PM2.5、PM10 或 NO2 的调整增强了儿童 O3 的关联，但没有观察到这些污染物的关联。在健康的大学生群体中，童年接触 O3 可能是 CIMT 的一个新的危险因素。对空气污染物的监管以及限制儿童接触空气污染物的努力仍然是重要的公共卫生目标。
Exposure to ambient air pollutants increases risk for cardiovascular health outcomes in adults. The contribution of childhood air pollutant exposure to cardiovascular health has not been thoroughly evaluated. The Testing Responses on Youth study consists of 861 college students recruited from the University of Southern California in 2007–2009. Participants attended one study visit during which blood pressure, heart rate and carotid artery intima-media thickness (CIMT) were assessed. Self-administered questionnaires collected information about health and socio-demographic characteristics and a 12-hr fasting blood sample was drawn for lipid and biomarker analyses. Residential addresses were geocoded and used to assign cumulative air pollutant exposure estimates based on data derived from the U.S. Environmental Protection Agency’s Air Quality System (AQS) database. The associations between CIMT and air pollutants were assessed using linear regression analysis. Mean CIMT was 603 μm (± 54 SD). A 2 standard deviation (SD) increase in childhood (aged 0–5 years) or elementary school (aged 6–12) O3 exposure was associated with a 7.8 μm (95% CI −0.3, 15.9) or 10.1 μm (95% CI 1.8, 18.5) higher CIMT, respectively. Lifetime exposure to O3 showed similar but non-significant associations. No associations were observed for PM2.5, PM10 or NO2 although adjustment for these pollutants strengthened the childhood O3 associations. Childhood exposure to O3 may be a novel risk factor for CIMT in a healthy population of college students. Regulation of air pollutants and efforts that focus on limiting childhood exposures continue to be important public health goals.