Organization of ion channels in the myelinated nerve fiber.
Organization of ion channels in the myelinated nerve fiber.
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有髓神经纤维中离子通道的组织。
DOI：
10.1126/science.2409596
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Ritchie,JM
中科院分区：
文献类型：
--
作者：
Waxman,SG;Ritchie,JM
哺乳动物有髓神经纤维的功能组织复杂而精致。与膜结构相对统一的无髓轴突相比，哺乳动物有髓轴突表现出高度的区域特化，延伸到轴突膜内电压依赖性离子通道的位置。钠离子和钾离子通道被分离到互补的膜结构域，其分布反映了上覆的雪旺细胞或胶质细胞的分布。这种组织的复杂性对生理学和病理生理学具有重要意义，特别是关于髓鞘纤维的发育。
The functional organization of the mammalian myelinated nerve fiber is complex and elegant. In contrast to nonmyelinated axons, whose membranes have a relatively uniform structure, the mammalian myelinated axon exhibits a high degree of regional specialization that extends to the location of voltage-dependent ion channels within the axon membrane. Sodium and potassium channels are segregated into complementary membrane domains, with a distribution reflecting that of the overlying Schwann or glial cells. This complexity of organization has important implications for physiology and pathophysiology, particularly with respect to the development of myelinated fibers.