Synthesis and characterization of novel biodegradable and biocompatible poly(ester-urethane) thin films prepared by homogeneous solution polymerization
Synthesis and characterization of novel biodegradable and biocompatible poly(ester-urethane) thin films prepared by homogeneous solution polymerization
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DOI：
10.1016/j.polymer.2008.07.057
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发表时间：
2008-09-23
期刊：
影响因子：
4.6
通讯作者：
Otaigbe, Joshua U.
中科院分区：
文献类型：
--
作者：
Wang, Wenshou;Guo, Yanlin;Otaigbe, Joshua U.
以聚己内酯二醇、二羟甲基丙酸和亚甲基二苯基二异氰酸酯为原料，在丙酮中原位均相溶液聚合，然后用水交换溶剂，合成了可生物降解的新型生物相容性聚(酯-氨酯)S。通过差示扫描量热法、热重分析法和热重分析法研究了DMPA含量和硬段含量对聚氨酯性能的影响。结果表明，DMPA对粒子大小有显著影响，随着DMPA含量的增加，粒子的大小迅速减小。降解实验表明，在所考察的范围内，DMPA含量对降解速率影响不大，但受硬段含量影响较大。细胞毒性分析表明，S合成的可生物降解的聚(酯-氨基甲酸酯)对人脐静脉内皮细胞和小鼠胚胎干细胞无明显毒性。这两种类型的细胞都能有效地附着和铺展在纯聚己内酯或聚酯氨酯S的表面。本研究证明了一种简单的合成可生物降解的聚氨酯及其具有特定性能的水分散体用于生物医学应用的可行性。(C)2008爱思唯尔有限公司。保留所有权利。
Novel biodegradable and biocompatible poly(ester-urethane)s were synthesized by in situ homogeneous solution polymerization of poly(epsilon-caprolactone) diol, dimethylolpropionic acid (DMPA), and methylene diphenyl diisocyanate in acetone followed by solvent exchange with water. The effects of the DMPA content and hard segment content on the properties of the polyurethanes were measured by DSC, TGA, and hydrolytic degradation measurements. The results showed that DMPA had a dramatic effect on the particle size; the particle size decreased rapidly with increasing DMPA content. The hydrolytic degradation test showed that the degradation rate was little affected by the DMPA content in the range investigated, but was observed to be influenced by the hard segment content. Cell toxicity analysis showed that the biodegradable poly(ester-urethane)s synthesized in this study did not exhibit any detectable toxicity to human umbilical vein endothelial cells and mouse embryonic stem cells. Both types of cells can effectively adhere to and spread on the surface of pure poly(epsilon-caprolactone) or poly(esterurethane)s. The present study demonstrates the feasibility of a facile synthesis of biodegradable polyurethanes and of their aqueous dispersions with prescribed properties for biomedical applications. (c) 2008 Elsevier Ltd. All rights reserved.