MACROCYCLIC ANTIFUNGAL METABOLITES FROM THE SPANISH DANCER NUDIBRANCH HEXABRANCHUS-SANGUINEUS AND SPONGES OF THE GENUS HALICHONDRIA
MACROCYCLIC ANTIFUNGAL METABOLITES FROM THE SPANISH DANCER NUDIBRANCH HEXABRANCHUS-SANGUINEUS AND SPONGES OF THE GENUS HALICHONDRIA
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DOI：
10.1021/jo00256a021
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发表时间：
1988-10-14
影响因子：
3.6
通讯作者：
FAULKNER, DJ
中科院分区：
文献类型：
--
作者：
KERNAN, MR;MOLINSKI, TF;FAULKNER, DJ
一种海绵Halichondria sp.含有主要成分halichondramide（4）和次要代谢产物dihydrohalichondramide（6）、isohalichondramide（10）和11、imide 12和ester 13。从裸鳃六鳃鱼中分离得到的化合物因采集地点不同而异，但通常包括二氢卤代软骨酰胺（6）和四氢卤代软骨酰胺（8）。大环内酯4、6、8和10具有抗真菌活性，并在受精海胆卵测定中抑制细胞分裂。
A marine sponge Halichondria sp. contained halichondramide (4) as the major constituent and dihydrohalichondramide (6), isohalichondramide (10), and 11, imide 12, and ester 13 as minor metabolites. The compounds isolated from the nudibranch Hexabranchus sanguineus varied depending on collecting location but usually included dihydrohalichondramide (6) and tetrahydrohalichondramide (8). The macrolides 4, 6, 8, and 10 have antifungal activity and inhibit cell division in the fertilized sea urchin egg assay.