Endogenous repair after spinal cord contusion injuries in the rat
Endogenous repair after spinal cord contusion injuries in the rat
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DOI：
10.1006/exnr.1997.6695
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发表时间：
1997-12-01
影响因子：
5.3
通讯作者：
Young, W
中科院分区：
文献类型：
--
作者：
Beattie, MS;Bresnahan, JC;Young, W
使用为多中心动物脊髓损伤研究（MASCIS）开发的标准化装置造成大鼠胸脊髓的挫伤。研究不同严重程度的损伤在损伤后6周内内源性修复的迹象。挫伤产生了一个典型的图片的二次损伤，导致破坏的脊髓中心和慢性保留的周边边缘的纤维，其数量取决于损伤的程度。值得注意的是，腔通常形成致密的细胞基质，其中部分填充有神经纤维和相关的许旺细胞。纤维和雪旺细胞长入的数量与损伤的严重程度和周围纤维保留的数量呈负相关。向内生长的纤维的来源是不确定的，但他们中的许多人显然起源于背根。除了再生的迹象，我们注意到位于中央管周围的室管膜区的细胞增殖的证据在早期挫伤损伤后。这些细胞可能有助于细胞小梁的发育，细胞小梁在病变腔内提供支架，为细胞浸润和轴突再生提供基质。总之，这些观察结果表明，脊髓挫伤的内源性修复反应是实质性的。了解修复过程的调节和限制可能会导致更好的方法，鼓励中枢神经系统损伤后的自发恢复。(C)北京：科学出版社.
Contusion injuries of the rat thoracic spinal cord were made using a standardized device developed for the Multicenter Animal Spinal Cord Injury Study (MASCIS). Lesions of different severity were studied for signs of endogenous repair at times up to 6 weeks following injury. Contusion injuries produced a typical picture of secondary damage resulting in the destruction of the cord center and the chronic sparing of a peripheral rim of fibers which varied in amount depending upon the injury magnitude. It was noted that the cavities often developed a dense cellular matrix that became partially filled with nerve fibers and associated Schwann cells. The amount of fiber and Schwann cell ingrowth was inversely related to the severity of injury and amount of peripheral fiber sparing. The source of the ingrowing fibers was not, determined, but many of them clearly originated in the dorsal roots. In addition to signs of regeneration, we noted evidence for the proliferation of cells located in the ependymal zone surrounding the central canal at early times following contusion injuries. These cells may contribute to the development of cellular trabeculae that provide a scaffolding within the lesion cavity that provides the substrates for cellular infiltration and regeneration of axons. Together, these observations suggest that the endogenous reparative response to spinal contusion injury is substantial. Understanding the regulation and restrictions on the repair processes might lead to better ways in which to encourage spontaneous recovery after CNS injury. (C) 1997 Academic Press.