Magnetic nanotubes for magnetic-field-assisted bioseparation, biointeraction, and drug delivery
Magnetic nanotubes for magnetic-field-assisted bioseparation, biointeraction, and drug delivery
复制标题
DOI：
10.1021/ja0517365
复制
发表时间：
2005-05-25
影响因子：
15
通讯作者：
Lee, SB
中科院分区：
文献类型：
--
作者：
Son, SJ;Reichel, J;Lee, SB
纳米颗粒的管状结构由于它们的结构属性（例如独特的内表面和外表面）而比常规的球形纳米颗粒具有高度吸引力。内部空隙可用于捕获，浓缩和释放大小从大蛋白质到小分子的物质。独特的外表面可以用环境友好的和/或针对特定靶标的探针分子进行差异化功能化。磁性颗粒在生物医学和生物技术应用领域得到了广泛的研究，包括药物输送、生物传感器、化学和生化分离和微量特定目标的浓缩以及磁共振成像（MRI）中的对比度增强。因此，通过结合有吸引力的管状结构和磁性，磁性纳米管（MNT）可以成为生物医学应用的多功能纳米材料的理想候选者，例如具有MRI能力的靶向药物递送。在这里，我们成功地合成了磁性二氧化硅-氧化铁复合纳米管，并展示了磁场辅助化学和生化分离，免疫结合和药物输送。
Tubular structure of nanoparticles is highly attractive due to their structural attributes, such as the distinctive inner and outer surfaces, over conventional spherical nanoparticles. Inner voids can be used for capturing, concentrating, and releasing species ranging in size from large proteins to small molecules. Distinctive outer surfaces can be differentially functionalized with environment-friendly and/or probe molecules to a specific target. Magnetic particles have been extensively studied in the field of biomedical and biotechnological applications, including drug delivery, biosensors, chemical and biochemical separation and concentration of trace amounts of specific targets, and contrast enhancement in magnetic resonance imaging (MRI). Therefore, by combining the attractive tubular structure with magnetic property, the magnetic nanotube (MNT) can be an ideal candidate for the multifunctional nanomaterial toward biomedical applications, such as targeting drug delivery with MRI capability. Here, we successfully synthesized magnetic silica−iron oxide composite nanotubes and demonstrated the magnetic-field-assisted chemical and biochemical separations, immunobinding, and drug delivery.