Increased water transport in PDMS silicone films by addition of excipients
Increased water transport in PDMS silicone films by addition of excipients
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DOI：
10.1016/j.actbio.2011.09.022
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发表时间：
2012-02-01
影响因子：
9.7
通讯作者：
Larsson, Anette
中科院分区：
文献类型：
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作者：
Borde, Annika;Larsson, Mikael;Larsson, Anette
旨在用于长时间应用的新的粘合剂伤口护理产品的开发需要粘合剂的良好的水输送性能，以维持伤口周围的合适环境。基于聚二甲基硅氧烷（PDMS）的有机硅膜传输水的能力导致其在皮肤压敏粘合剂中的使用，并且找到控制或增加水穿过PDMS膜的传输的方法以便能够开发改进的皮肤粘合剂将是有利的。在这项研究中，我们提出了一种方法，以增加水的运输，在这样的电影通过添加亲水性赋形剂。研究了三种亲水性添加剂，高水溶性蔗糖和两种高吸水性聚合物（SAP）Carbopol（R）和Pemulen（TM）。通过水转运研究、溶胀试验、扫描电子显微镜成像和共聚焦显微镜对辅料的作用进行表征。交联聚合物，主要是Pemulen（TM），是有效的水传输增强剂，而蔗糖没有显示出任何效果。添加剂的效果似乎与它们的水结合能力相关。对于SAP，还建议通过溶胀聚合物形成溶胀结构，这通过具有较高扩散常数的区域（溶胀SAP）的较高体积分数来增强水渗透，从而导致通过整个膜的更快传输。(C)2011 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
The development of new adhesive wound care products intended for an application over a prolonged time requires good water transporting properties of the adhesive for the maintenance of a suitable environment around the wound. The ability of polydimethylsiloxane (PDMS)-based silicone films to transport water has led to its use in skin pressure-sensitive adhesives and it would be advantageous to find ways for controlling or increasing water transport across PDMS films in order to be able to develop improved skin adhesives. In this study we present a way to increase water transport in such films by the addition of hydrophilic excipients. Three hydrophilic additives, highly water-soluble sucrose and the two superabsorbent polymers (SAP) Carbopol (R) and Pemulen (TM), were investigated. The effect of the excipients was characterized by water transport studies, swelling tests, scanning electron microscopy imaging and confocal microscopy. The cross-linked polymers, primarily Pemulen (TM), were efficient water transport enhancers, whereas sucrose did not show any effect. The effect of the additives seemed to correlate with their water binding capacity. For SAPs the formation of a percolating structure by swollen polymer was also suggested, which enhances water penetration by the higher volume fraction of areas with a higher diffusion constant (swollen SAP), leading to a faster transport through the entire film. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.