Definition and identification of homology domains.
Definition and identification of homology domains.
复制标题
同源域的定义和识别。
DOI：
10.1093/bioinformatics/4.1.25
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Goldman,DA
中科院分区：
文献类型：
--
作者：
Lawrence,CB;Goldman,DA
描述了一种用于识别和评估两个序列之间显著相似区域的方法。采用“同源域”的概念来定义序列同源区域的边界，该区域不包含插入或删除。不同的潜在同源域的相对重要性是用一个非线性的相似性分数来评估的，这个分数与偶然发现该区域的观察到的相似性水平的概率有关。通过模拟同源域的演化并将该方法应用于同源域的检测，证明了该方法的灵敏度。给出了几个使用同源域识别的例子。
A method is described for identifying and evaluating regions of significant similarity between two sequences. The notion of a ‘homology domain’ is employed which defines the boundaries of a region of sequence homology containing no insertions or deletions. The relative significance of different potential homology domains is evaluated using a non-linear similarity score related to the probability of finding the observed level of similarity in the region by chance. The sensitivity of the method is demonstrated by simulating the evolution of homology domains and applying the method to their detection. Several examples of the use of homology domain identification are given.