MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas
MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas
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DOI：
10.1136/jcp.2004.023572
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发表时间：
2005-08-01
影响因子：
3.4
通讯作者：
Yonezawa, S
中科院分区：
文献类型：
--
作者：
Saitou, M;Goto, M;Yonezawa, S
背景：许多胰腺浸润性导管癌（IDC）患者预后不佳。MUC4的表达是IDC的诊断和预后的重要指标，但MUC4的表达与IDC患者预后的关系尚未见报道。目的：探讨MUC4在IDC中的表达与预后的关系。方法：采用免疫组化方法检测135例IDC组织中MUC4、ErbB2、p27和MUC1的表达。135例IDC中43例（31.9%）表达MUC4。21名MUC 4高表达患者的生存率（。114例MUC4低表达患者（< 20%的肿瘤细胞染色）的结果显著差于114例MUC4低表达患者（< 20%的肿瘤细胞染色）（p = 0.0043）。单因素分析显示，高MUC4表达（p = 0.0061）、大原发肿瘤状态（> T2）（p = 0.0436）、远处转移（p = 0.0383）、淋巴浸润（p = 0.0243）和手术切缘（p = 0.0333）是影响IDC患者预后的重要危险因素。后向逐步多因素分析显示MUC4表达（p = 0.0121）、淋巴结转移（p = 0.0245）和淋巴管浸润（p = 0.0239）是显著的独立危险因素。ErbB2、p27和MUC1不是独立的危险因素。结论：本研究表明MUC4在IDC中的表达是一个新的预后不良的独立因素，可预测IDC患者的预后。
Background: Many patients with invasive ductal carcinoma of the pancreas ( IDC) have a poor outcome. MUC4 expression has been implicated as a marker for diagnosis and progression of IDC, but there are no studies of the relation between MUC4 expression and patient prognosis in IDC.Aims: To investigate the prognostic significance of MUC4 expression in IDC.Methods: The expression profiles of MUC4, ErbB2, p27, and MUC1 were investigated in IDC tissues from 135 patients by means of immunohistochemistry.Results: MUC4 was expressed in 43 of the 135 patients with IDC ( 31.9%). The survival of 21 patients with high MUC4 expression (. 20% of neoplastic cells stained) was significantly worse than that of the 114 patients with low MUC4 expression ( < 20% of neoplastic cells stained) ( p = 0.0043). Univariate analysis showed that high MUC4 expression ( p = 0.0061), large primary tumour status (> T2) ( p = 0.0436), distant metastasis ( p = 0.0383), lymphatic invasion ( p = 0.0243), and surgical margins ( p = 0.0333) were significant risk factors affecting the outcome of patients with IDC. Backward stepwise multivariate analysis showed that MUC4 expression ( p = 0.0121), lymph node metastasis ( p = 0.0245), and lymphatic invasion ( p = 0.0239) were significant independent risk factors. ErbB2, p27, and MUC1 were not independent risk factors.Conclusions: This study shows that MUC4 expression in IDC is a new independent factor for poor prognosis and predicts the outcome of patients with IDC.