The next generation: Urinary epidermal growth factor is associated with an early decline in kidney function in children and adolescents with type 1 diabetes mellitus
The next generation: Urinary epidermal growth factor is associated with an early decline in kidney function in children and adolescents with type 1 diabetes mellitus
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DOI：
10.1016/j.diabres.2021.108945
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发表时间：
2021-07-14
影响因子：
5.1
通讯作者：
Trouet, Dominique
中科院分区：
文献类型：
--
作者：
Ledeganck, Kristien J.;den Brinker, Marieke;Trouet, Dominique
目的：微量白蛋白尿被认为是糖尿病肾病的早期临床体征，然而，在微量白蛋白尿出现之前数年就可出现早期肾小球滤过率降低。在这项研究中，我们探讨了尿表皮生长因子（uEGF）是否可以作为儿童和青少年糖尿病肾病的早期标志物相比，微量白蛋白尿。方法：选择1型糖尿病患儿158例，健康对照组40例。采集血清和尿液样本三次，间隔至少一个月，以测定肌酐（血清和尿液）、表皮生长因子和白蛋白（尿液）。从电子患者文件中提取人口统计学数据和常规实验室检查值。结果：与健康对照组相比，T1 DM儿童的uEGF显著降低（p = 0.032）。相对较低的肾小球滤过率（eGFR）与uEGF降低相关（p < 0.001）。在多变量分析中，uEGF与eGFR独立相关。结论：uEGF可作为儿童和青少年糖尿病肾病的早期标志物。(c)2021作者（S）由Elsevier B. V.发布。这是CC BY NC-ND许可下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Aims: Micro-albuminuria is considered an early clinical sign of diabetes nephropathy, however, early decrease of glomerular filtration can be present years before the presence of microalbuminuria. In this study, we explored whether urinary epidermal growth factor (uEGF) might serve as an early marker of diabetes nephropathy compared to microalbuminuria in children and adolescents. Methods: Children with type 1 diabetes mellitus (n = 158) and healthy controls (n = 40) were included in this study. Serum and urine samples were collected three times with an interval of at least one month to determine creatinine (serum and urine), epidermal growth factor and albumin (urine). Demographic data and routine lab values were extracted out of the electronic patient files. Results: uEGF was significantly lower in children with T1DM compared to healthy controls (p = 0.032). A relatively lower glomerular filtration rate (eGFR) was associated with a decreased uEGF (p < 0.001). uEGF was independently associated with eGFR in a multivariate analysis. Conclusion: This study provides evidence that uEGF can serve as an early marker of diabetes nephropathy in children and adolescents. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).