CD86 gene variants and susceptibility to pancreatic cancer
CD86 gene variants and susceptibility to pancreatic cancer
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DOI：
10.1007/s00432-012-1289-9
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发表时间：
2012-12-01
影响因子：
3.6
通讯作者：
Hu, Zhiqian
中科院分区：
文献类型：
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作者：
Xiang, Honggang;Zhao, Wei;Hu, Zhiqian
背景胰腺癌是全世界最致命的癌症之一。 CD86 (B7-2) 是抗原呈递细胞上的共刺激分子，在肿瘤免疫中发挥着关键作用。据报道，CD86基因的多态性可能参与多种癌症的发生发展。在此，我们研究了两个CD86多态性，+1057G/A（rs1129055）和+2379G/C（rs17281995）与中国人群胰腺癌的关联。方法采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）在369名胰腺癌患者和412名健康对照中鉴定这两个多态性。通过卡方检验分析数据，并根据体重指数、吸烟、饮酒和糖尿病状况进行调整。 结果 结果显示，胰腺癌病例中 +1057A 等位基因的频率显着高于对照组（59.8% vs. 52.8%，p = 0.021）。基因型频率比较显示，+1057GA 和 +1057AA 基因型在胰腺癌组中显着增加（比值比 (OR) = 1.52；95% 置信区间 (CI)，1.09-2.38；p = 0.026；OR = 1.90；95% CI，1.21-3.01；p = 0.007）。我们没有发现+2379G/C 多态性与胰腺癌之间存在任何关联。单倍型分析表明，AG（+1057，+2379）单倍型与该疾病的易感性相关（p = 0.019）。结论这些结果表明CD86+1057G/A多态性和AG（+1057，+2379）单倍型是胰腺癌的遗传危险因素。
Background Pancreatic cancer is one of the most lethal cancers worldwide. CD86 (B7-2) is a costimulatory molecule on antigen-presenting cells and plays critical roles in tumor immunity. It has been reported that polymorphisms in CD86 gene can be involved in the development of various cancers. Here, we investigated the association of two CD86 polymorphisms, +1057G/A (rs1129055) and +2379G/C (rs17281995), with pancreatic cancer in the Chinese population.Methods The two polymorphisms were identified in 369 pancreatic cancer patients and 412 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Data were analyzed by chi-square test and adjusted for body mass index, smoking, drinking, and diabetes status.Results Results showed that the frequency of the +1057A allele was significantly higher in pancreatic cancer cases than in controls (59.8 vs. 52.8 %, p = 0.021). Comparison of genotype frequencies showed that +1057GA and +1057AA genotypes were significantly increased in the pancreatic cancer group (odds ratio (OR) = 1.52; 95 % confidence interval (CI), 1.09-2.38; p = 0.026; and OR = 1.90; 95 % CI, 1.21-3.01; p = 0.007). We did not find any association between the +2379G/C polymorphism and pancreatic cancer. Analysis of haplotypes indicated that the AG (+1057, +2379) haplotype was correlated with the susceptibility to this disease (p = 0.019).Conclusions These results suggest that the CD86 +1057G/A polymorphism and AG (+1057, +2379) haplotype are genetic risk factors for pancreatic cancer.