Ossification of the ligamentum flavum: Diet and genetics
Ossification of the ligamentum flavum: Diet and genetics
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DOI：
10.1016/j.jocn.2006.01.010
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发表时间：
2007-07-01
影响因子：
2
通讯作者：
Dvorak, Marcel
中科院分区：
文献类型：
--
作者：
Mobbs, Ralph J.;Dvorak, Marcel
骨化黄韧带（OLF）被认为是胸椎脊髓神经根病的重要原因。然而，尽管有许多流行病学和基础科学研究，OLF的发病机制尚未最终确定。骨化和症状发展在日本人群中明显更常见，因此支持疾病过程的遗传偏好。我们提出了一个不寻常的情况下，OLF患者从低风险的遗传背景（中国），暴露在青年的生活方式和饮食从高风险人群（日本）。基于我们的病例报告，我们支持饮食习惯可能是OLF和后纵韧带骨化的独立危险因素的观点。(c)2006年由Elsevier Ltd.出版
Ossified ligamentum flavum (OLF) is being appreciated as an important cause of thoracic myeloradiculopathy. However, despite numerous epidemiological and basic science studies, the pathogenesis of OLF has not been conclusively established. Ossification and symptom development are significantly more frequent in the Japanese population, therefore supporting a genetic predilection for the disease process. We present an unusual case of OLF in a patient from a low-risk genetic background (Chinese), exposed in youth to a lifestyle and diet from a high-risk population (Japanese). Based on our case report, we support the view that dietary habits may constitute an independent risk factor for OLF and ossification of the posterior longitudinal ligament. (c) 2006 Published by Elsevier Ltd.