Arsenic Exposure From Drinking Water, Arsenic Methylation Capacity, and Carotid Intima-Media Thickness in Bangladesh
Arsenic Exposure From Drinking Water, Arsenic Methylation Capacity, and Carotid Intima-Media Thickness in Bangladesh
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DOI：
10.1093/aje/kwt001
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发表时间：
2013-08-01
影响因子：
5
通讯作者：
Ahsan, Habibul
中科院分区：
文献类型：
--
作者：
Chen, Yu;Wu, Fen;Ahsan, Habibul
我们进行了一项横断面研究，以评估既往砷暴露、砷暴露敏感性特异性生物标志物和颈动脉内膜中层厚度（cIMT）之间的相互关系，研究对象为来自孟加拉国砷对健康影响纵向研究的959名受试者。我们在2010 - 2011年期间测量了基线后平均7.2年的cIMT水平。砷暴露量在基线时的井水和在基线和随访期间收集的尿样中进行测量。尿砷（357.9 g/g肌酐）和井水砷（102.0 g/L）浓度每增加1个标准差，cIMT分别增加11.7 m（95置信区间（CI）：1.8，21.6）和5.1 m（95 CI：0.2，10.3）。一甲基胂酸（MMA）百分比每增加10，cIMT增加12.1 m（95 CI：0.4，23.8）。在尿MMA百分比较高、尿MMA与无机砷的比率较高以及二甲基胂酸与MMA的比率较低的参与者中，井水砷与cIMT之间的关联更强。研究结果表明，过去长期砷暴露对cIMT的影响，这可能是由次优或不完全的砷甲基化能力增强。未来的前瞻性研究需要证实砷甲基化能力和动脉粥样硬化相关结果之间的关联。
We conducted a cross-sectional study to evaluate the interrelationships between past arsenic exposure, biomarkers specific for susceptibility to arsenic exposure, and carotid intima-media thickness (cIMT) in 959 subjects from the Health Effects of Arsenic Longitudinal Study in Bangladesh. We measured cIMT levels on average 7.2 years after baseline during 20102011. Arsenic exposure was measured in well water at baseline and in urine samples collected at baseline and during follow-up. Every 1-standard-deviation increase in urinary arsenic (357.9 g/g creatinine) and well-water arsenic (102.0 g/L) concentration was related to a 11.7-m (95 confidence interval (CI): 1.8, 21.6) and 5.1-m (95 CI: 0.2, 10.3) increase in cIMT, respectively. For every 10 increase in monomethylarsonic acid (MMA) percentage, there was an increase of 12.1 m (95 CI: 0.4, 23.8) in cIMT. Among participants with a higher urinary MMA percentage, a higher ratio of urinary MMA to inorganic arsenic, and a lower ratio of dimethylarsinic acid to MMA, the association between well-water arsenic and cIMT was stronger. The findings indicate an effect of past long-term arsenic exposure on cIMT, which may be potentiated by suboptimal or incomplete arsenic methylation capacity. Future prospective studies are needed to confirm the association between arsenic methylation capacity and atherosclerosis-related outcomes.