Decreased extracellular pH inhibits osteogenesis through proton-sensing GPR4-mediated suppression of yes-associated protein.
Decreased extracellular pH inhibits osteogenesis through proton-sensing GPR4-mediated suppression of yes-associated protein.
复制标题
细胞外 pH 值降低通过质子感应 GPR4 介导的 yes 相关蛋白抑制抑制成骨
DOI：
10.1038/srep26835
复制
发表时间：
2016-06-03
影响因子：
4.6
通讯作者：
Zhang CQ
中科院分区：
文献类型：
--
作者：
Tao SC;Gao YS;Zhu HY;Yin JH;Chen YX;Zhang YL;Guo SC;Zhang CQ
The pH of extracellular fluids is a basic property of the tissue microenvironment and is normally maintained at 7.40 ± 0.05 in humans. Many pathological circumstances, such as ischemia, inflammation, and tumorigenesis, result in the reduction of extracellular pH in the affected tissues. In this study, we reported that the osteogenic differentiation of BMSCs was significantly inhibited by decreases in the extracellular pH. Moreover, we demonstrated that proton-sensing GPR4 signaling mediated the proton-induced inhibitory effects on the osteogenesis of BMSCs. Additionally, we found that YAP was the downstream effector of GPR4 signaling. Our findings revealed that the extracellular pH modulates the osteogenic responses of BMSCs by regulating the proton-sensing GPR4-YAP pathway.
