Increase in Incidence of Colorectal Cancer Among Young Men and Women in the United States
Increase in Incidence of Colorectal Cancer Among Young Men and Women in the United States
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DOI：
10.1158/1055-9965.epi-09-0186
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发表时间：
2009-06-01
影响因子：
3.8
通讯作者：
Ward, Elizabeth M.
中科院分区：
文献类型：
--
作者：
Siegel, Rebecca L.;Jemal, Ahmedin;Ward, Elizabeth M.
最近结直肠癌发病率的加速下降在很大程度上归因于50岁及以上成年人筛查率的增加。我们使用了13个监测、流行病学和最终结果癌症登记处的数据，报告了1992年至2005年50岁以下成年人的结直肠癌发病率趋势，这些人不建议按性别、种族/民族、年龄、诊断阶段和解剖亚部位对平均风险人群进行筛查。总体而言，1992年至2005年，每10万名年轻人（20-49岁）的结直肠癌发病率在男性中每年增加1.5%，在女性中每年增加1.6%。在非西班牙裔白人中，男性和女性在每个10岁年龄组（20-29岁、30-39岁和40-49岁）和每个诊断阶段的发病率都有所增加。非西班牙裔白人发病率的增加主要是由直肠癌引起的，在13年的研究期间，男性每年平均增加3.5%，女性每年平均增加2.9%。与美国结直肠癌发病率总体下降的趋势相反，50岁以下男性和女性的发病率正在上升。需要进一步的研究来阐明这一趋势的原因，并确定潜在的预防和早期发现策略。（癌症流行病学杂志，2009;18(6):1695- 98）
The recent, accelerated decline in colorectal cancer incidence rates has largely been attributed to an increase in screening rates among adults 50 years and older. We used data from 13 Surveillance, Epidemiology, and End Results cancer registries to report on colorectal cancer incidence trends from 1992 through 2005 among adults under age 50 years, for whom screening is not recommended for persons at average risk, by sex, race/ethnicity, age, stage at diagnosis, and anatomic subsite. Overall, incidence rates of colorectal cancer per 100,000 young individuals (ages 20-49 years) increased 1.5% per year in men and 1.6% per year in women from 1992 to 2005. Among non-Hispanic Whites, rates increased for both men and women in each 10-year age grouping (20-29, 30-39, and 40-49 years) and for every stage of diagnosis. The increase in incidence among non-Hispanic Whites was predominantly driven by rectal cancer, for which there was an average increase of 3.5% per year in men and 2.9% per year in women over the 13-year study interval. In contrast to the overall decreasing trend in colorectal cancer incidence in the United States, rates are increasing among men and women under age 50 years. Further studies are necessary to elucidate causes for this trend and identify potential prevention and early detection strategies. (Cancer Epidemiol Biomarkers Prev 2009;18(6):1695-8)