Serum docosahexaenoic acid (DHA) is inversely associated with anxiety disorders in early pregnancy
Serum docosahexaenoic acid (DHA) is inversely associated with anxiety disorders in early pregnancy
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DOI：
10.1016/j.janxdis.2014.12.002
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发表时间：
2015-03-01
影响因子：
10.3
通讯作者：
Kac, Gilberto
中科院分区：
文献类型：
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作者：
Barbosa Verly-Miguel, Marcus Vinicius;Farias, Dayana Rodrigues;Kac, Gilberto
关于多不饱和脂肪酸（PUFA）与怀孕期间焦虑症之间的关系知之甚少。我们对 228 名女性在怀孕头三个月时的这种关联进行了评估。研究终点是通过小型国际神经精神病学访谈评估的任何焦虑症的诊断。自变量是总 n-3 和组分 (18:2,20:5, 22:5,22:6)、总 n-6 和组分 (18:2、18:3、20:2、20:3、20:4、22:4、22:5) 的血清浓度以及 n-6/n-3 PUFA 比率。任何焦虑症的患病率为 25%。在调整胎次、家庭收入、早期妊娠 BMI 和采血时孕龄的分析后，与第二和第三个三分位数相比，二十二碳六烯酸（DHA，22:6 n-3）分布的第一个三分位数代表焦虑症诊断的可能性高 1.95（95% Cl：1.00-3.77）。 DHA 血清浓度与早孕焦虑症的发生呈负相关。 (C) 2014 Elsevier Ltd. 保留所有权利。
Little is known about the association between polyunsaturated fatty acids (PUFAs) and anxiety disorders during pregnancy. We evaluated this association at the first pregnancy trimester in 228 women. The study endpoint was the diagnosis of any anxiety disorder assessed by the Mini International Neuropsychiatric Interview. The independent variables were the serum concentrations of total n-3 and fractions (18:2,20:5, 22:5,22:6), total n-6 and fractions (18:2, 18:3, 20:2, 20:3, 20:4, 22:4, 22:5) and the n-6/n-3 ratio PUFAs. The prevalence of any anxiety disorders was 25%. The first tertile of the docosahexaenoic acid (DHA, 22:6 n-3) distribution represented 1.95 (95% Cl: 1.00-3.77) higher chance of having an anxiety disorder diagnosis, compared to those in the second and third tertiles after adjusting the analyses for parity, family income, early pregnancy BMI and gestational age at the blood sampling. Serum concentrations of DHA were inversely associated with the occurrence of early pregnancy anxiety disorders. (C) 2014 Elsevier Ltd. All rights reserved.