CHANGING RELATION BETWEEN ONSET OF MYELINATION AND AXON DIAMETER RANGE IN DEVELOPING FELINE WHITE MATTER
CHANGING RELATION BETWEEN ONSET OF MYELINATION AND AXON DIAMETER RANGE IN DEVELOPING FELINE WHITE MATTER
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DOI：
10.1016/0022-510x(82)90216-7
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发表时间：
1982-01-01
影响因子：
4.4
通讯作者：
HILDEBRAND, C
中科院分区：
文献类型：
--
作者：
REMAHL, S;HILDEBRAND, C
通过电镜检查发育过程中猫的脊髓腹索和胼胝体中无髓鞘、有鞘和最初有髓鞘的中枢神经系统轴突的尺寸谱。第一个髓鞘分别于出生前 4 周和出生后 3 周出现在脊柱和胼胝体区域。 4 个月时，从头髓鞘形成基本停止。在腹侧索和 7 个月时。在胼胝体中。如果比较相似的髓鞘形成水平，则脊髓和胼胝体轴突经历初级鞘和初始髓鞘形成的直径范围明显不同。在这两个区域中，这些直径范围随着发展而转向更小的尺寸。脊柱和胼胝体轴突同时经历初级鞘和初始髓鞘形成，呈现出可比的直径范围。除了轴突的绝对物理尺寸之外的其他因素显然会引发中枢神经系统髓鞘形成的启动。在这方面，动物的发育阶段似乎发挥着重要作用。
The size spectra of unmyelinated, ensheathed and initially myelinating CNS axons were examined by EM in the spinal cord ventral funiculus and the corpus callosum of the cat during development. The first myelin sheaths appeared 4 wk before and 3 wk after birth in the spinal and callosal areas, respectively. De novo myelination had largely ceased by 4 mo. in the ventral funiculus and by 7 mo. in the corpus callosum. The diameter ranges, within which spinal and callosal axons undergo primary ensheathment and initial myelination, are markedly different if similar levels of myelination are compared. In both areas, these diameter ranges shift towards smaller sizes with development. Spinal and callosal axons, which undergo primary ensheathment and initial myelination simultaneously, present comparable diameter rangesd. Other factors than the absolute physical size of the axon apparently trigger initiation of CNS myelination. In this respect the developmental stage of the animal appears to play an important role.