An optimal permissible source region strategy for multispectral bioluminescence tomography
An optimal permissible source region strategy for multispectral bioluminescence tomography
复制标题
多光谱生物发光断层扫描的最佳允许源区域策略
DOI：
10.1364/oe.16.015640
复制
发表时间：
2008-09-29
期刊：
影响因子：
3.8
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Feng, Jinchao;Jia, Kebin;Tian, Jie
多光谱生物发光层析成像(BLT)在小动物研究领域受到越来越多的关注，因为多光谱数据采集可以帮助生物发光源的三维定位。通常情况下，BLT问题是不适定的，对于唯一和定量地重建生物发光源来说，先验信息是必不可少的。在本文中，我们提出了一种基于最优允许源区策略的光谱分辨生物发光层析成像算法。与以往研究的最大不同之处在于，提出了一种无需人工干预自动选择最优允许源区的策略，以减少BLT的不适定性，从而提高重建质量。此外，数值稳定性和计算效率都得益于该策略。在数值实验中，使用异质模型对所提出的算法进行了评估，并用蒙特卡罗方法产生了避免反犯罪的合成数据。结果表明，我们的方法在重建生物发光源的分布方面是可行的和潜在的。(C)2008年美国光学学会
Multispectral bioluminescence tomography (BLT) attracts increasing more attention in the area of small animal studies because multispectral data acquisition could help in the 3D location of bioluminescent sources. Generally, BLT problem is ill-posed and a priori information is indispensable to reconstruction bioluminescent source uniquely and quantitatively. In this paper, we propose a spectrally solved bioluminescence tomography algorithm with an optimal permissible source region strategy. Being the most different from earlier studies, an optimal permissible source region strategy which is automatically selected without human intervention is developed to reduce the ill-posedness of BLT and therefore improves the reconstruction quality. Furthermore, both numerical stability and computational efficiency benefit from the strategy. In the numerical experiments, a heterogeneous phantom is used to evaluate the proposed algorithm and the synthetic data is produced by Monte Carlo method for avoiding the inverse crime. The results demonstrate the feasibility and potential of our methodology for reconstructing the distribution of bioluminescent sources. (C) 2008 Optical Society of America