Quantification of the effect of energy imbalance on bodyweight.
Quantification of the effect of energy imbalance on bodyweight.
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DOI：
10.1016/s0140-6736(11)60812-x
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发表时间：
2011-08-27
期刊：
影响因子：
168.9
通讯作者：
Swinburn, Boyd A.
中科院分区：
文献类型：
--
作者：
Hall, Kevin D.;Sacks, Gary;Chandramohan, Dhruva;Chow, Carson C.;Wang, Y. Claire;Gortmaker, Steven L.;Swinburn, Boyd A.
肥胖干预可以导致体重减轻，但准确预测体重时间进程需要适当考虑动态能量失衡。在这份报告中，我们描述了一种成人新陈代谢的数学模型方法，它模拟了减肥期间能量消耗的适应。我们还提出了一个基于Web的模拟器，用于预测权重变化动态。我们发现，体重对能量摄入量变化的反应是缓慢的，大约是一年的一半。此外，肥胖程度较高的成年人在相同的能量摄入变化下预期减重更多，达到稳定体重所需的时间将比那些最初身体脂肪较少的人所需的时间更长。使用人口平均模型，我们计算了与美国成人肥胖症流行发展相对应的能量平衡动态。每天大约30kJ的摄入量和消耗量之间持续的小的平均每日能量不平衡差距是观察到的平均体重增加的基础。然而，能量摄入量必须增加，才能跟上与体重增加相关的支出增加的步伐。维持体重增加所需的能量摄入量(维持能量缺口)平均每天增加约0.9MJ，并量化了扭转肥胖流行的公共卫生挑战。
Obesity interventions can result in weight loss, but accurate prediction of the bodyweight time course requires properly accounting for dynamic energy imbalances. In this report, we describe a mathematical modelling approach to adult human metabolism that simulates energy expenditure adaptations during weight loss. We also present a web-based simulator for prediction of weight change dynamics. We show that the bodyweight response to a change of energy intake is slow, with half times of about 1 year. Furthermore, adults with greater adiposity have a larger expected weight loss for the same change of energy intake, and to reach their steady-state weight will take longer than it would for those with less initial body fat. Using a population-averaged model, we calculated the energy-balance dynamics corresponding to the development of the US adult obesity epidemic. A small persistent average daily energy imbalance gap between intake and expenditure of about 30 kJ per day underlies the observed average weight gain. However, energy intake must have risen to keep pace with increased expenditure associated with increased weight. The average increase of energy intake needed to sustain the increased weight (the maintenance energy gap) has amounted to about 0·9 MJ per day and quantifies the public health challenge to reverse the obesity epidemic.