CONSEQUENCES OF WIDESPREAD DEREGULATION OF THE C-MYC GENE IN TRANSGENIC MICE - MULTIPLE NEOPLASMS AND NORMAL DEVELOPMENT
CONSEQUENCES OF WIDESPREAD DEREGULATION OF THE C-MYC GENE IN TRANSGENIC MICE - MULTIPLE NEOPLASMS AND NORMAL DEVELOPMENT
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DOI：
10.1016/0092-8674(86)90280-1
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发表时间：
1986-05-23
期刊：
影响因子：
64.5
通讯作者：
LEDER, P
中科院分区：
文献类型：
--
作者：
LEDER, A;PATTENGALE, PK;LEDER, P
我们构建了一个转基因小鼠株系，其中乳腺肿瘤病毒LTR/c-myc融合基因在多种组织中异常表达。C-myc转基因，现在是糖皮质激素诱导的，导致各种肿瘤的发病率增加，包括睾丸、乳腺、淋巴细胞(B细胞和T细胞)和肥大细胞起源的肿瘤。然而，去调控基因不会在其他方面干扰细胞增殖，也不会干扰这些动物的正常发育。此外，由于并不是所有表达转基因的组织都会发生肿瘤，这些结果开始定义c-myc癌基因的转化谱。它们还延伸到几个器官系统，即除了激活的c-myc基因外，还需要一些元件来在活的有机体中诱导恶性肿瘤。
We have constructed a transgenic mouse strain in which a mammary tumor virus LTR/c-myc fusion gene is anomalously expressed in a wide variety of tissues. The deregulated c-myc transgene, now glucocorticoid inducible, contributes to an increased incidence of a variety of tumors, including those of testicular, breast, lymphocytic (B cell and T cell), and mast cell origin. The deregulation gene does not, however, otherwise disturb cell proliferation, nor does it interfere with normal development in these animals. Moreover, since not all tissues that express the transgene develop neoplasms, these results begin to define the transforming spectrum of the c-myc oncogene. They also extend to several organ systems the notion that elements in addition to an activated c-myc gene are required to induce malignancy in the living organism.