Coquillette, a sea urchin T-box gene of the Tbx2 subfamily, is expressed asymmetrically along the oral-aboral axis of the embryo and is involved in skeletogenesis
Coquillette, a sea urchin T-box gene of the Tbx2 subfamily, is expressed asymmetrically along the oral-aboral axis of the embryo and is involved in skeletogenesis
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DOI：
10.1016/s0925-4773(03)00022-4
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发表时间：
2003-05-01
影响因子：
2.6
通讯作者：
Gache, C
中科院分区：
文献类型：
--
作者：
Croce, J;Lhomond, G;Gache, C
T结构域家族的转录因子调节许多发育过程。我们从海胆中分离出了Tbx2亚家族的一个新成员：Coquillette。Coquillette有一种晚期合子表达，其定位是动态的：在囊胚期，它被限制在大多数假定的外胚层和内胚层区域的倒生侧，从原肠发育到倒生的最初级间充质细胞。Coquillette函数的扰动延迟了原肠形成，并强烈地破坏了幼虫的骨骼。Coquillette对口腔-流产(OA)轴的改变很敏感，我们发现控制外胚层中口腔和流产命运的鹅类可能是一种上游调节因子。考奎莱特似乎是沿着OA轴的图案系统的一个组成部分。(C)2003爱思唯尔爱尔兰科学有限公司。保留所有权利。
Transcription factors of the T-domain family regulate many developmental processes. We have isolated from the sea urchin a new member of the Tbx2 subfamily: coquillette. Coquillette has a late zygotic expression whose localization is dynamic: at the blastula stage it is restricted to the aboral side of most of the presumptive ectoderm and endoderm territories and from gastrulation on, to the aboral-most primary mesenchyme cells. Perturbation of coquillette function delays gastrulation and strongly disorganizes the skeleton of the larva. Coquillette is sensitive to alteration of the oral-aboral (OA) axis and we identify goosecoid, which controls oral and aboral fates in the ectoderm, as a probable upstream regulator. Coquillette appears to be an integral part of the patterning system along the OA axis. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.