X-chromosomal markers: Past, present and future
X-chromosomal markers: Past, present and future
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DOI：
10.1016/j.fsigen.2007.03.003
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发表时间：
2007-06-01
影响因子：
3.1
通讯作者：
Szibor, Reinhard
中科院分区：
文献类型：
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作者：
Szibor, Reinhard
在临床遗传学方面获得的经验导致了在法医学的广泛应用中使用X染色体标记的基本想法。迄今为止，已将30多个可疑交易报告确定为法证标记。紧密连锁的STR的联合分型产生稳定的单倍型，并可用于建立远亲之间的关系，如阿姨-侄女对和堂兄弟姐妹。对于这些应用，现在可在市场上买到的新的ChrX分型试剂盒ArgusX-8（R）是一个强大的工具。本文对法医学X染色体检验的历史发展作了简要回顾，并对法医学X染色体检验的现状和未来进行了讨论。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Experience gained in clinical genetics led to the fundamental idea of using X-chromosomal markers in a wide range of forensic applications. To date more than 30 STRs have been established as forensic markers. Joint typing of very tightly linked STRs yields stable haplotypes, and can be used for establishing the relationship between distant relatives, such as aunt-niece pairs and cousins. For such applications the new ChrX typing kit ArgusX-8 (R) which is commercially available now is a powerful tool. This paper is aimed at presenting a brief survey of historical developments and discussing present and future aspects of forensic X-chomosomal testing. (c) 2007 Elsevier Ireland Ltd. All rights reserved.