Biocompatible Polymer Nanoformulation To Improve the Release and Safety of a Drug Mimic Molecule Detectable via ICP-MS
Biocompatible Polymer Nanoformulation To Improve the Release and Safety of a Drug Mimic Molecule Detectable via ICP-MS
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DOI：
10.1021/acs.molpharmaceut.6b00753
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发表时间：
2017-01-01
影响因子：
4.9
通讯作者：
Moscatelli, Davide
中科院分区：
文献类型：
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作者：
Ferrari, Raffaele;Talamini, Laura;Moscatelli, Davide
合成了基于荧光聚e-己内酯的纳米粒子（NPs），并成功地装载了钛有机金属化合物作为水不溶性药物的模拟物。该纳米载体的性质使我们能够结合对健康免疫小鼠系统给药后组织中金属的定量，通过电感耦合等离子体质谱（ICP-MS），然后通过共聚焦显微镜观察器官切片中的NPs。这种创新的纳米药物筛选方法使我们能够阐明其动力学的关键参数。有机金属化合物是大多数抗癌药物的良好模拟物，这种方法是一个有趣的起点，可以在安全性和靶向递送方面设计广泛的纳米配方。
Fluorescent poly(e-caprolactone)-based nano-particles (NPs) have been synthesized and successfully loaded with a titanium organometallic compound as a mimic of a water-insoluble drug. The nature of this nanovector enabled us to combine the quantification of the metal in tissues after systemic administration in healthy immunocompetent mice by inductively coupled plasma mass spectroscopy (ICP-MS) followed by the visualization of NPs in organ sections by confocal microscopy. This innovative method of nanodrug screening has enabled us to elucidate the crucial parameters of their kinetics. The organometallic compound is a good mimic of most anticancer drugs, and this approach is an interesting starting point to design the relevance of a broad range of nanoformulations in terms of safety and targeted delivery of the cargoes.