Relationship between the microvascular patterns observed by magnifying endoscopy with narrow-band imaging and the depth of invasion in superficial pharyngeal squamous cell carcinoma
Relationship between the microvascular patterns observed by magnifying endoscopy with narrow-band imaging and the depth of invasion in superficial pharyngeal squamous cell carcinoma
复制标题
窄带成像放大内镜观察浅表咽鳞状细胞癌微血管形态与浸润深度的关系
DOI：
10.1007/s10388-020-00754-5
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发表时间：
2020
期刊：
影响因子：
2.4
通讯作者：
Yano Tomonori
中科院分区：
文献类型：
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作者：
Sunakawa Hironori;Hori Keisuke;Kadota Tomohiro;Shinmura Kensuke;Yoda Yusuke;Ikematsu Hiroaki;Tomioka Toshifumi;Akimoto Tetsuo;Hayashi Ryuichi;Fujii Satoshi;Yano Tomonori
研究背景预测浸润深度是消化道癌内镜观察的目的。在浅表性食管癌中，通过窄带成像放大内窥镜（M-NBI）观察到的微血管模式与病理浸润深度之间的密切关系是众所周知的。 M-NBI 预测浅表咽鳞状细胞癌 (SPSCC) 浸润深度的能力很少被评估。本研究旨在阐明SPSCC微血管模式与病理深度之间的关系。方法对2010年4月至2017年3月期间经M-NBI评估并进行内镜切除的SPSCC病灶进行分析。根据日本食管协会分类，内镜图像分为B1、B2和B3型微血管肿瘤。浸润的病理深度被描述为原位鳞状细胞癌（Tis）或浸润性上皮下癌，并检查所有病灶的肿瘤厚度。使用unpairedt、χ2或Mann-Whitney U检验对数据进行分析。结果B1型和B2/B3型(35/3)微血管分别在180个病变(82%)和39个(18%)中发现。在扁平病变中，115 个 (83%) 被分类为 Tis，23 个 (17%) 被分类为上皮下癌。 B1 血管的阳性和阴性预测值分别为 77% 和 82%。进一步分析显示，B1血管对扁平型病变的阳性预测值为87%；对隆起病灶的阴性预测值为93%。结论M-NBI观察到的微血管模式是预测病理浸润深度的重要因素。
BackgroundPrediction of the invasive depth is the objective of endoscopic observation for digestive cancer. In superficial esophageal cancer, a close relationship between microvascular patterns observed by magnifying endoscopy with narrow-band imaging (M-NBI) and pathological depth of invasion is well known. The ability of M-NBI to predict the invasion depth in superficial pharyngeal squamous cell carcinoma (SPSCC) has been seldom evaluated. This study aimed to clarify the relationship between the microvasculature patterns and pathological depth in SPSCC.MethodsSPSCC lesions evaluated with M-NBI followed by endoscopic resection were analyzed between April 2010 and March 2017. Endoscopic images were classified as microvasculature tumor types B1, B2, and B3 according to the Japan Esophageal Society classification. The pathological depth of invasion was described as either squamous cell carcinoma in situ (Tis) or invasive subepithelial cancer, and the tumor thickness of all lesions was examined. Data were analyzed using the unpairedt,χ2, or Mann–Whitney U test.ResultsType B1 and type B2/B3 (35/3) microvessels were found in 180 lesions (82%) and 39 (18%), respectively. Of the flat lesions, 115 (83%) were classified as Tis and 23 (17%) as subepithelial cancer. Positive and negative predictive values of the B1 vessels were 77% and 82%, respectively. Additional analysis showed that the positive predictive value of the B1 vessels for the flat-type lesions was 87%; the negative predictive value for the elevated lesions was 93%.ConclusionsMicrovascular patterns observed by M-NBI are an important factor in predicting the pathological depth of invasion.