New Cytotoxic Metabolites from the Marine-Derived Fungus Penicillium sp ZLN29
New Cytotoxic Metabolites from the Marine-Derived Fungus Penicillium sp ZLN29
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来自海洋源性真菌青霉菌 ZLN29 的新细胞毒性代谢物
DOI：
10.1002/hlca.201200596
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发表时间：
2013-03-01
影响因子：
1.8
通讯作者：
Zhu, Tian-Jiao
中科院分区：
文献类型：
--
作者：
Gao, Huquan;Zhou, Lina;Zhu, Tian-Jiao
One new penicillide derivative, prenpenicillide (1), and one new xanthone derivative, prenxanthone (2), were isolated from the culture extract of the marine-derived fungus Penicillium sp. ZLN29, together with six known polyketide compounds, 38. Their structures were elucidated on the basis of spectroscopic and spectrometric analyses. The cytotoxicities of these eight compounds were evaluated on four tumor-cell lines by SRB (=sulforhodamine B) or MTT (=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) methods. Compounds 1 and 3 exhibited weak cytotoxicities against HepG2 cell line with IC50 values of 9.9 and 9.7M, respectively.
