STEREOSPECIFICITY OF DIACYLGLYCEROL FOR STIMULUS-RESPONSE COUPLING IN PLATELETS
STEREOSPECIFICITY OF DIACYLGLYCEROL FOR STIMULUS-RESPONSE COUPLING IN PLATELETS
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DOI：
10.1016/0006-291x(86)90754-0
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发表时间：
1986-11-14
影响因子：
3.1
通讯作者：
SATOH, T
中科院分区：
文献类型：
--
作者：
NOMURA, H;ASE, K;SATOH, T
In intact platelets, a permeable diacylglycerol having a 1,2-sn- but not 2,3-sn-configuration activated protein kinase C directly. In the presence of Ca2+-ionophore this diacylglycerol caused full activation of platelet release reaction. 1,3-Isomer was inactive. Among these isomers only 1,2-sn-diacylglycerol was converted rapidly to the corresponding phosphatidic acid in both intact and broken cell preparations. Thus, the diacylglycerol which functions in stimulus-response coupling possesses a 1,2-sn-glycerol backbone, and other isomers are not involved in the signal transduction through the protein kinase C pathway.
