The effects of hypoxia, premature birth, infection, ototoxic drugs, circulatory system and congenital disease on neonatal hearing loss
The effects of hypoxia, premature birth, infection, ototoxic drugs, circulatory system and congenital disease on neonatal hearing loss
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DOI：
10.1016/j.anl.2004.07.007
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发表时间：
2004-12-01
影响因子：
1.7
通讯作者：
Kobayashi, T
中科院分区：
文献类型：
--
作者：
Yoshikawa, S;Ikeda, K;Kobayashi, T
目的：调查新生儿听力损失的发病率在良好的婴儿人群和新生儿重症监护病房，并确认听力损失的潜在危险因素，在新生儿重症监护病房的婴儿听力联合委员会（JCIH）没有recommended.Methods：听力筛查进行了226名婴儿（452耳）出生在东北大学2000年至2001年。这些病例包括1241名健康新生儿（248耳）和102名在新生儿重症监护室（NICU）接受治疗的新生儿（204耳）。通过自动听音器、脑干反应（AABR）的初步筛查和耳鼻喉科评估的听性脑干反应（ABR）的二次测试证实听力受损。基于这些检查。结果：通过我们的方案，将9例（15耳）新生儿分为“合格”和“合格”两组。转诊组的发生率在婴儿保育室为0.8%（1/124），在NICU人群中为7.8%（8/102）。转介组婴儿先天性感染发生率明显高于对照组（P < 0.01）。高C反应蛋白（CRP）（≥ 10 mg/dl）。染色体畸变。中枢神经系统异常（P < 0.05）。从另一方面来说。新生儿重症监护室通过组和转诊组之间的出生体重（0.1）无统计学差异。呼吸状态，如Apgar评分（外观，脉搏，鬼脸，活动的缩写。呼吸）（1 min;小于等于4）、（5 min;小于等于6）、Silverman退缩评分、耳毒性药物使用、呼吸窘迫综合征（RDS）、胎粪吸入综合征（MAS）和新生儿持续性肺动脉高压（PPHN）也与听力损失无统计学相关性（>0.999）。听力损失与先天性感染呈正相关。高CRP（≥ 10 mg/dl）、染色体畸变和中枢神经系统异常。CRP（大于或等于10 mg/dl）变量未列入JCIH发布的高危登记册，但我们可以说该变量可能预测我们患者人群的听力损伤。当新生儿无其他致菲斯克因素时，耳聋基因可能为常染色体隐性遗传。这使我们得出结论，听力筛查是发现听力损失人群的有效方法。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Objectives: To investigate the incidence of neonatal hearing loss in well-baby populations and in a neonatal intensive care unit and to idenfify potential risk factors for hearing loss in a neonatal intensive care unit which the Joint Committee on Infant Hearing (JCIH) had not recommended.Methods: Auditory screening was conducted in 226 infants (452 ears) born in Tohoku University from 2000 to 2001. The cases included 1241 healthy newborn infants (248 ears), and 102 newborn infants (204 ears) treated in the neonatal intensive care unit (NICU). Hearing impairment was confirmed through a primary screening of the automated auditor), brainstem response (AABR) and a secondary test of the auditory brainstem response (ABR) with otolaryngologic evaluation. Based on these examinations. we divided infants into two groups, 'Pass' and 'Mer'.Results: Nine patients (15 ears) in Refer group were identified through our protocol. The incidence of the Refer group was 0.8% (1 out of 124) in the well-baby nursery, 7.8% (8 out of 102) in the NICU Populations. The infants in Refer group were shown to have a higher incidence of congenital infection (P < 0.01). high C-reactive protein (CRP) (greater than or equal to10 mg/dl). chromosomal aberration. and central nervous system abnormality (P < 0.05). On the other hand. there were no statistical differences between the Pass and Refer groups in NICU, birth weight ( 0.1). Respiratory status such as the Apgar score (the abbreviation for appearance, pulse, grimace, activity. respiration) (1 min; less than or equal to4), (5 min; less than or equal to6), Silverman retraction score, ototoxic drug use, respiratory distress Syndrome (RDS), Meconium aspiration syndrome (MAS), and persistent pulmonary hypertension of newborn (PPHN) were also not statistically related to hearing loss (>0.999).Conclusion: Even in a small number of infants. there are positive relationships between hearing loss and congenital infection. high CRP (greater than or equal to10 mg/dl), chromosomal aberration and central nervous system abnormality. The CRP (greater than or equal to10 mg/dl) variable are, not listed in the high-risk register published by the JCIH, but we can say that the variable may predict hearing impairment in our patient population. The possibility of autosomal recessive inheritance of genes for deafness is Supposed when newborns have no other fisk factors for hearing loss. This leads us to conclude that hearing screening is an effective way to find out hearing loss population. (C) 2004 Elsevier Ireland Ltd. All rights reserved.