The bed nucleus of the stria terminalis is critically involved in enhancing associative learning after stressful experience
The bed nucleus of the stria terminalis is critically involved in enhancing associative learning after stressful experience
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DOI：
10.1037/0735-7044.119.6.1459
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发表时间：
2005-12-01
影响因子：
1.9
通讯作者：
Shors, TJ
中科院分区：
文献类型：
--
作者：
Bangasser, DA;Santollo, J;Shors, TJ
暴露于急性应激事件增强了雄性大鼠的微量眨眼条件反射，即使大鼠在应激源后开始训练也是如此（Shots，2001）。作者研究了终纹的床核（BNST），一个涉及压力和焦虑的区域，是否在这种影响中起关键作用，如果是，什么时候。作者发现，BNST的兴奋性毒性损伤阻止了应激暴露后的增强条件反射。此外，暂时失活的BNST在应激过程中没有改变增强响应，而在训练过程中失活防止增强。这些数据表明，压力的经验，诱导持续的变化，在BNST是必要的，以提高学习后，压力事件已经停止。
Exposure to an acute stressful event enhances trace eyeblink conditioning in male rats, even when rats begin training days after the stressor (Shots, 2001). The authors examined whether the bed nucleus of the stria terminalis (BNST), an area involved in stress and anxiety, is critically involved in this effect and, if so, when. The authors found that excitotoxic lesions to the BNST prevented the enhanced conditioning after stressor exposure. In addition, temporary inactivation of the BNST during the stressor did not alter enhanced responding, whereas inactivation during training prevented the enhancement. These data indicate that stressful experience induces persistent changes in the BNST that are necessary for enhancing learning well after the stressful event has ceased.