A COMPARATIVE-STUDY OF THE REPRODUCTIVE EFFECTS OF METHADONE AND BENZO[A]PYRENE IN THE PREGNANT AND PSEUDOPREGNANT RAT
A COMPARATIVE-STUDY OF THE REPRODUCTIVE EFFECTS OF METHADONE AND BENZO[A]PYRENE IN THE PREGNANT AND PSEUDOPREGNANT RAT
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DOI：
10.1016/0300-483x(86)90009-0
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发表时间：
1986-12-01
期刊：
影响因子：
4.5
通讯作者：
WEST, WL
中科院分区：
文献类型：
--
作者：
BUI, QQ;TRAN, MB;WEST, WL
将苯并[α]芘(BP；50mg/kg)或美沙酮(5mg/kg)皮下给予不同妊娠阶段的怀孕大鼠。 BP和美沙酮都通过显着增加吸收和胎儿损耗的数量以及降低胎儿体重来影响怀孕大鼠的繁殖性能。相同剂量水平的 BP 和美沙酮也被给予诱导蜕膜细胞反应 (DCR) 的假孕大鼠 (PSP)，试图区分母体或胎儿室或两者是否发生不良反应。由于 DCR 和着床的激素需求相似，并且 DCR 和蜕膜的解剖学、组织学、细胞学、时间顺序变化以及脉管系统的外观无法区分，因此具有 DCR 的 PSP 与妊娠相似，只是缺少胎儿隔室。在此 PSP 模型中，BP 显着降低了子宫湿重以及环核苷酸 (cAMP) 和 (cGMP) 水平，而美沙酮则没有可检测到的效果。我们的研究结果表明，血压可能对母体和胎儿室产生不利影响，而美沙酮可能主要作用于胎儿室。
Benzo[.alpha.]pyrene (BP; 50 mg/kg) or methadone (5 mg/kg) was given subcutaneously to pregnant rats at different stages of gestation. Both BP and methadone affected the reproductive performance of pregnant rats by significantly increasing the number of resorptions and fetal wastage, and by decreasing the fetal weight. The same dosage levels of BP and methadone were also given to pseudopregnant rats (PSP) with an induced decidual cell reaction (DCR) in an attempt to distinguish whether adverse effects occur in the maternal or fetal compartment or both. Since the hormonal requirements for DCR and implantation are similar and the anatomical, histological, cytological, time sequential changes as well as appearance of the vasculature system for DCR and decidua are indistinguishable, PSP with DCR is similar to pregnancy except for the lack of a fetal compartment. BP, in this PSP model, significantly reduced the uterine wet weight and cyclic nucleotide (cAMP) and (cGMP) levels whereas methadone was without a detectable effect. Our findings then suggest that BP may exert its effects adversely on both the maternal and fetal compartments, whereas methadone may act primarily in the fetal compartment.