Selective binding of carcinoembryonic antigen using imprinted polymeric hydrogels
Selective binding of carcinoembryonic antigen using imprinted polymeric hydrogels
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DOI：
10.1002/jbm.a.31757
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发表时间：
2008-11-01
影响因子：
4.9
通讯作者：
Kofinas, Peter
中科院分区：
文献类型：
--
作者：
Casey, Brendan J.;Kofinas, Peter
采用水溶性交联剂乙二醇二缩水甘油醚合成了聚烯丙胺盐酸盐癌胚抗原印迹水凝胶，研究了其对蛋白质的识别能力。印迹凝胶对癌胚抗原的印迹因子被发现是类似于5，而印迹凝胶对甲胎蛋白的印迹因子被确定为类似于2，这表明对模板蛋白的选择性和特异性。这项工作奠定了基础，开发一种新的线的印迹水凝胶系统能够识别蛋白质的诊断和治疗应用。(c)2008 Wiley Periodicals，Inc.
A poly(allylamine hydrochloride) carcinoembryonic antigen-imprinted hydrogel,was synthesized using a water-soluble crosslinker, ethylene glycol diglycidyl ether, to investigate its viability for protein recognition. The imprinting factor of the imprinted hydrogel toward carcinoembryonic antigen was found to be similar to 5, while the imprinting factor of the imprinted hydrogel toward alpha-fetoprotein was determined to be similar to 2, suggesting selectivity and specificity toward the template protein. This work lays the foundation for the development of a novel line of imprinted hydrogel systems capable of protein recognition for diagnostic and therapeutic applications. (c) 2008 Wiley Periodicals, Inc.