ELECTROCHEMICAL PROPERTIES OF TYROSINE PHENOXY AND TRYPTOPHAN INDOLYL RADICALS IN PEPTIDES AND AMINO-ACID-ANALOGS
ELECTROCHEMICAL PROPERTIES OF TYROSINE PHENOXY AND TRYPTOPHAN INDOLYL RADICALS IN PEPTIDES AND AMINO-ACID-ANALOGS
复制标题
肽和氨基酸类似物中酪氨酸苯氧基和色氨酸吲哚基的电化学性质
DOI：
10.1021/j100161a081
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发表时间：
1991-04-18
影响因子：
--
通讯作者：
KLAPPER, MH
中科院分区：
文献类型：
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作者：
DEFELIPPIS, MR;MURTHY, CP;KLAPPER, MH
本文报道的是酪氨酸苯氧基（tyrO）的氧化还原电位。和色氨酸吲哚基（trp.）含有酪氨酸或色氨酸残基的肽中的自由基。这些测定与脉冲辐解，循环伏安法和微分脉冲极谱电化学技术。 脉冲辐解和电化学方法产生可比的结果。 在不同的含有色氨酸和酪氨酸的肽之间，氧化还原电位存在微小差异（相对于游离氨基酸）;在色氨酸的情况下，这些变化可能与肽中氨基酸的位置相关。 我们还提出了一些酪氨酸和色氨酸衍生物的氧化还原电位和色氨酸自由基阳离子的酸/碱性质，当自由和肽结合。
Reported here are the redox potentials of the tyrosine phenoxy (tyrO.) and tryptophan indolyl (trp.) radicals in peptides containing tyrosine or tryptophan residues. These were determined with pulse radiolysis, and the electrochemical techniques of cyclic voltammetry and differential pulse polarography. The pulse radiolytic and electrochemical methods yield comparable results. There are small differences (relative to the free amino acid) in redox potentials among the different tryptophan and tyrosine containing peptides; in the case of tryptophan these changes may correlate with the position of amino acid in the peptide. We also present the redox potentials of some tyrosine and tryptophan derivatives and the acid/base properties of the tryptophan radical cation, when both free and peptide bound.