Regional myocardial substrate uptake in hypertensive rats: a quantitative autoradiographic measurement.
Regional myocardial substrate uptake in hypertensive rats: a quantitative autoradiographic measurement.
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DOI：
10.1126/science.3975623
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发表时间：
1985-03
期刊：
影响因子：
56.9
通讯作者：
Yoshiharu Yonekura;A. Brill;Peter M. Som;K. Yamamoto;Suresh C. Srivastava;J. Iwai;David R. Elmaleh;E. Livni;Strauss Hw;M. Goodman
中科院分区：
文献类型：
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作者：
Yoshiharu Yonekura;A. Brill;Peter M. Som;K. Yamamoto;Suresh C. Srivastava;J. Iwai;David R. Elmaleh;E. Livni;Strauss Hw;M. Goodman
严重高血压引起心肌灌注和底物利用的整体和局部改变。采用双示踪放射自显影技术评价正常和高血压大鼠达尔菌株的局部灌注和脂肪酸利用情况。正常血压大鼠灌注和脂肪酸利用的区域分布是均匀的。严重的高血压与局部灌注的均匀模式有关，但脂肪酸的利用在左心室自由壁局部减少。脂肪酸摄取的减少与葡萄糖利用的增加有关。这些发现表明，严重高血压与心肌灌注均匀性和心肌功能底物的局灶性改变有关。
Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive rats. Severe hypertension was associated with a homogeneous pattern of regional perfusion, but fatty acid utilization was focally decreased in the free wall of the left ventricle. The decrease in fatty acid uptake was associated with a concomitant increase in glucose utilization. These findings suggest that severe hypertension is associated with uniform myocardial perfusion and focal alterations in the substrates used for the performance of myocardial work.