Serum Lipids and Lipoproteins at Birth in a Biracial Population: The Bogalusa Heart Study
Serum Lipids and Lipoproteins at Birth in a Biracial Population: The Bogalusa Heart Study
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混血儿人群出生时的血清脂质和脂蛋白：Bogalusa 心脏研究
DOI：
10.1203/00006450-197808000-00011
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发表时间：
1978
影响因子：
3.6
通讯作者：
G. Berenson
中科院分区：
文献类型：
--
作者：
R. Frerichs;S. Srinivasan;L. Webber;Marc C Rieth;G. Berenson
总结：本文报告了在路易斯安那州博加卢萨出生18个月的419名黑人和白色婴儿（占合格人群的94%）的脐带血血脂、总胆固醇、甘油三酯和脂蛋白（β;-、前β;-和α-）。出生时，白色新生儿的总胆固醇和β-脂蛋白的平均水平高于黑人新生儿。在四个种族性别组中，白色女孩的脐带血总胆固醇、β-脂蛋白和α-脂蛋白水平最高。无论是分娩时的压力，出生体重，社会经济地位，也没有一年中的季节有任何脂质或脂蛋白水平的可观察到的影响。脐带血中各自的脂质和脂蛋白之间关系的大小和方向与我们在同一社区的学龄前和学龄儿童中观察到的相似。总胆固醇与β-和α-脂蛋白高度相关;甘油三酯与前β-脂蛋白相关，但与α-脂蛋白呈负相关。这些观察结果表明，基本的生化关系已经建立在birth.Speculation：脐带血中的脂质和脂蛋白水平提供了有用的基线数据，用于评估儿童脂蛋白谱的演变。通过阐明这些因素作为决定因素的脂质和脂蛋白在脐带血中，我们可能会更接近了解一般人群中的脂质调节机制。
Summary: The lipid profile, total cholesterol, triglycerides, and lipoproteins (β;-, pre-β;-, and α-) of cord blood, is presented for 419 black and white infants (94% of the eligible population) born during an 18-month period in Bogalusa, Louisiana. At birth, white neonates of both sexes had higher average levels than black neonates of total cholesterol and β;-lipoproteins. White girls among the four race-sex groups had the highest cord blood levels of total cholesterol, β;-ipoproteins, and α-lipoproteins. Neither stress at delivery, birth weight, socioeconomic status, nor season of the year had an observable effect on any of the lipid or lipoprotein levels. The magnitude and direction of the relationships between the respective lipids and lipoproteins in cord blood were similar to those we have observed in preschool and school-aged children in the same community. Total cholesterol was highly correlated with both β;-and α-lipoproteins; triglycerides were correlated with pre-β;-lipo-proteins but inversely with α-lipoproteins. These observations suggest that basic biochemical relationships are already established at birth.Speculation: The lipid and lipoprotein levels in cord blood provide useful baseline data for evaluating the evolution of lipoprotein profiles in children. By elucidating those factors which serve as determinants of lipids and lipoproteins in cord blood, we may come closer to understanding the lipid regulatory mechanisms in the general population.