SYMPTOM PATTERNS IN UNIPOLAR AND BIPOLAR DEPRESSION CORRELATING WITH MONOAMINE METABOLITES IN THE CEREBROSPINAL-FLUID .2. SUICIDE
SYMPTOM PATTERNS IN UNIPOLAR AND BIPOLAR DEPRESSION CORRELATING WITH MONOAMINE METABOLITES IN THE CEREBROSPINAL-FLUID .2. SUICIDE
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DOI：
10.1016/0165-1781(80)90039-6
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发表时间：
1980-01-01
影响因子：
11.3
通讯作者：
AGREN, H
中科院分区：
文献类型：
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作者：
AGREN, H
采用多元回归分析，对21例单相抑郁症和12例双相抑郁症患者的情感障碍和精神分裂症量表中的自杀倾向评分与CSF中的单胺代谢产物相关。自杀倾向单项最差周数与3-甲氧基-4-羟基苯乙二醇（MHPG）呈高度显著负相关，与5-羟基吲哚乙酸（5 HIAA）呈极轻微相关。生命早期最严重自杀企图的严重性与MHPG和5 HIAA均呈显著负相关。主观愤怒与自杀想法呈正相关，而公开愤怒与自杀想法呈负相关。研究结果支持了早期的报告，即低5 HIAA的抑郁症患者倾向于暴力自杀，但也指出了平等的，如果不是更大的，参与MHPG和去甲肾上腺素能神经元系统在执行一个死亡的愿望。
Suicidality scores from the Schedule for Affective Disorders and Schizophrenia on 21 unipolar and 12 bipolar depressives were correlated with monoamine metabolites in the CSF using multiple regression analyses. The single item of suicidal tendencies worst week correlated highly significantly and negatively with 3-methoxy-4-hydroxyphenylglycol (MHPG) and only to a very slight degree with 5-hydroxyindoleacetic acid (5HIAA). Seriousness of intent of worst suicide attempt earlier in life correlated significantly and negatively with both MHPG and 5HIAA. Subjective anger was positively and overt anger negatively associated with thoughts of suicide. The results support earlier reports that depressives with low 5HIAA are prone to violent suicides, but also point to the equal, if not even greater, involvement of MHPG and noradrenergic neuronal systems in carrying out a wish for death.