The role of Aurora B expression in non-tumor liver tissues of patients with hepatocellular carcinoma
The role of Aurora B expression in non-tumor liver tissues of patients with hepatocellular carcinoma
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DOI：
10.1007/s10147-013-0593-y
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发表时间：
2014-08-01
影响因子：
3.3
通讯作者：
Shimada, Mitsuo
中科院分区：
文献类型：
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作者：
Tovuu, Lkhagva-Ochir;Utsunomiya, Tohru;Shimada, Mitsuo
Aurora B是一种丝氨酸-苏氨酸激酶和染色体乘客蛋白，参与有丝分裂期间染色体组装和分离的控制。Aurora B的异常表达在一些肿瘤中已有报道，包括肺癌和肝细胞癌（HCC）。我们研究了Aurora B表达在HCC和匹配的邻近非肿瘤组织中的作用。采用定量逆转录-聚合酶链反应（RT-PCR）检测肿瘤组织和非肿瘤组织中Aurora B的表达。按中位数将患者分为高、低基因表达组，比较两组患者的临床病理资料，Aurora B在肿瘤组织中的表达明显高于非癌组织（P < 0.001）。无病生存期在肿瘤组织中高表达和低表达的组之间没有显著差异。在非肿瘤组织中，低表达组的无瘤生存率明显高于高表达组（P < 0.05）。Aurora B基因的表达水平与肝功能检测结果（如凝血酶原时间）相关，Aurora B在非癌组织中的表达可能是HCC的一个预后因子。
Aurora B is a serine-threonine kinase and chromosomal passenger protein involved in the control of chromosome assembly and segregation during mitosis. Aberrant expression of Aurora B has been reported in some tumors, including lung and hepatocellular carcinoma (HCC). We investigated the role of Aurora B expression in both HCC and matched adjacent non-tumor tissue.Sixty-three patients with HCC who underwent hepatic resection were enrolled in this study. Aurora B expression in tumor and non-tumor tissue was examined by use of quantitative reverse transcription-polymerase chain reaction. The patients were divided into high and low gene expression groups by median value, and clinicopathological data were compared between the two groups.Aurora B expression was significantly higher in tumor tissue than in non-cancerous tissue (P < 0.001). Disease-free survival was not significantly different between groups with high and low expression in the tumor tissues. For non-tumor tissues, disease-free survival of the low-expression group was significantly better than that of the high-expression group (P < 0.05). The gene expression level of Aurora B correlated with results from liver function tests, for example prothrombin time.Aurora B expression in non-cancerous tissues may be a prognostic factor for HCC.