Cortical thinning of temporal pole and orbitofrontal cortex in medication-naive children and adolescents with ADHD
Cortical thinning of temporal pole and orbitofrontal cortex in medication-naive children and adolescents with ADHD
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DOI：
10.1016/j.pscychresns.2014.07.004
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发表时间：
2014-10-30
影响因子：
2.3
通讯作者：
Calleja-Perez, Beatriz
中科院分区：
文献类型：
--
作者：
Fernandez-Jaen, Alberto;Lopez-Martin, Sara;Calleja-Perez, Beatriz
注意力缺陷/多动障碍（ADHD）的结构和功能脑研究主要检查了前额叶-纹状体回路（特别是前额叶皮层和背侧纹状体的背侧和外侧区域）的解剖异常。然而，越来越多的证据表明，几个颞叶区域可能在ADHD中发挥重要作用。本研究使用基于MRI的皮质厚度测量来检查未接受过药物治疗的ADHD患者（N=50）和年龄和性别匹配的典型发育对照组（N=50）之间前额叶和颞叶区域的可能差异。与健康对照组相比，ADHD患者右颞极和眶额皮质（OFC）的皮质厚度显著降低。在控制了年龄、总体平均皮质厚度和共病外化条件（如对立违抗和行为障碍）的混杂效应后，这些差异仍显着。这些结果表明颞极和眶额皮层参与了ADHD的神经病理学。此外，目前的研究结果为多个大脑区域和心理过程与ADHD相关的假设提供了证据。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Structural and functional brain studies on attention deficit/hyperactivity disorder (ADHD) have primarily examined anatomical abnormalities in the prefronto-striatal circuitry (especially, dorsal and lateral areas of the prefrontal cortex and dorsal striatum). There is, however, increased evidence that several temporal lobe regions could play an important role in ADHD. The present study used MRI-based measurements of cortical thickness to examine possible differences in both prefrontal and temporal lobe regions between medication-naive patients with ADHD (N=50) and age- and sex-matched typically developing controls (N=50). Subjects with ADHD exhibited significantly decreased cortical thickness in the right temporal pole and orbitofrontal cortex (OFC) relative to healthy comparison subjects. These differences remained significant after controlling for confounding effects of age, overall mean cortical thickness and comorbid externalizing conditions, such as oppositional defiant and conduct disorders. These results point to the involvement of the temporal pole and OFC in the neuropathology of ADHD. Moreover, present findings add evidence to the assumption that multiple brain regions and psychological processes are associated with ADHD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.