GLUCOCORTICOID STIMULATION OF BIOSYNTHESIS OF GLUTAMIC-ALANINE TRANSAMINASE
GLUCOCORTICOID STIMULATION OF BIOSYNTHESIS OF GLUTAMIC-ALANINE TRANSAMINASE
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DOI：
10.1073/pnas.50.5.912
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发表时间：
1963-01-01
影响因子：
11.1
通讯作者：
KIM, YS
中科院分区：
文献类型：
--
作者：
SEGAL, HL;KIM, YS
在正常大鼠和泼尼松龙治疗大鼠中，C14-亮氨酸掺入肝谷丙转氨酶的测量结果直接证明了在泼尼松治疗的动物中，该酶的生物合成速率提高了几倍。合成速率的提高先于并导致激素给药后酶的稳态组织水平的增加。酶的半衰期已被确定，发现在正常动物中为3.5天，在泼尼松龙治疗的动物中为1.2天。
Measurements of C14-leucine incorporation into liver glutamic-alanine transaminase in normal and prednisolone-treated rats has proved a direct demonstration of a severalfold greater rate of biosynthesis of the enzyme in the hormone-treated animals. The elevated rate of synthesis precedes and leads to the increase in the steady-state tissue level of the enzyme consequent to hormone administration. The half-life of the enzyme has been determined and found to be 3.5 days in normal animals and 1.2 days in prednisolone-treated animals.