Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization.
Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization.
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DOI：
10.1016/j.immuni.2021.08.009
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发表时间：
2021-11-09
期刊：
影响因子：
32.4
通讯作者：
Corry DB
中科院分区：
文献类型：
--
作者：
Wu Y;Zeng Z;Guo Y;Song L;Weatherhead JE;Huang X;Zeng Y;Bimler L;Chang CY;Knight JM;Valladolid C;Sun H;Cruz MA;Hube B;Naglik JR;Luong AU;Kheradmand F;Corry DB
真菌气道感染（气道真菌病）是过敏性气道疾病（如哮喘）的重要原因，但真菌触发哮喘反应的机制知之甚少。在这里，我们利用野生型和突变型白色念珠菌，以确定这种常见的真菌如何electives特征的Th 2和Th 17细胞依赖性过敏性气道疾病的小鼠。我们证明，而不是蛋白酶是霉菌的基本毒力因子，C。而白色念珠菌通过肽毒素念珠菌溶解素促进变应性气道疾病。白藜芦醇通过血管性血友病因子（VWF）受体GP 1b α激活血小板，释放Wnt拮抗剂Dickkopf-1（Dkk-1），驱动Th 2和Th 17细胞应答，与肺真菌负荷降低相关。血小板同时排除了真菌肺侵袭导致的致命性肺出血。因此，除了止血作用外，血小板还促进了对C.白念珠菌气道真菌病通过抗真菌途径，涉及念珠菌溶素，GP 1b α和Dkk-1，促进Th 2和Th 17反应。白念珠菌可引起Th 2和Th 17细胞依赖的过敏性气道疾病，但其发病机制尚不清楚。Wu等人，揭示了一种过敏效应途径，其中C.白色念珠菌因子念珠菌溶素通过血小板表达的GP 1b α发出信号，驱动dickkopf 1（Dkk-1）的释放，进而促进抗真菌T细胞应答。
Fungal airway infection (airway mycosis) is an important cause of allergic airway diseases such as asthma, but the mechanisms by which fungi trigger asthmatic reactions are poorly understood. Here, we leverage wild-type and mutant Candida albicans to determine how this common fungus elicits characteristic Th2 and Th17 cell-dependent allergic airway disease in mice. We demonstrate that rather than proteinases that are essential virulence factors for molds, C. albicans instead promoted allergic airway disease through the peptide toxin candidalysin. Candidalysin activated platelets through the Von Willebrand factor (VWF) receptor GP1bα to release the Wnt antagonist Dickkopf-1 (Dkk-1) to drive Th2 and Th17 cell responses that correlated with reduced lung fungal burdens. Platelets simultaneously precluded lethal pulmonary hemorrhage resulting from fungal lung invasion. Thus, in addition to hemostasis, platelets promoted protection against C. albicans airway mycosis through an antifungal pathway involving candidalysin, GP1bα, and Dkk-1 that promotes Th2 and Th17 responses. Candida albicans causes Th2 and Th17 cell-dependent allergic airway disease, but the pathogenesis is obscure. Wu, et al., reveal an allergic effector pathway in which the C. albicans factor candidalysin signals through platelet-expressed GP1bα to drive release of dickkopf 1 (Dkk-1) that in turn promotes antifungal T cell responses.
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影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
DOI：
10.1016/j.jaci.2014.12.1945
发表时间：
2015-08
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Engelhardt KR;Gertz ME;Keles S;Schäffer AA;Sigmund EC;Glocker C;Saghafi S;Pourpak Z;Ceja R;Sassi A;Graham LE;Massaad MJ;Mellouli F;Ben-Mustapha I;Khemiri M;Kilic SS;Etzioni A;Freeman AF;Thiel J;Schulze I;Al-Herz W;Metin A;Sanal Ö;Tezcan I;Yeganeh M;Niehues T;Dueckers G;Weinspach S;Patiroglu T;Unal E;Dasouki M;Yilmaz M;Genel F;Aytekin C;Kutukculer N;Somer A;Kilic M;Reisli I;Camcioglu Y;Gennery AR;Cant AJ;Jones A;Gaspar BH;Arkwright PD;Pietrogrande MC;Baz Z;Al-Tamemi S;Lougaris V;Lefranc G;Megarbane A;Boutros J;Galal N;Bejaoui M;Barbouche MR;Geha RS;Chatila TA;Grimbacher B
通讯作者：
Grimbacher B
影响因子：
5
作者：
Baurand, A;Raboisson, P;Gachet, C
通讯作者：
Gachet, C
影响因子：
16.6
作者：
Kasper L;König A;Koenig PA;Gresnigt MS;Westman J;Drummond RA;Lionakis MS;Groß O;Ruland J;Naglik JR;Hube B
通讯作者：
Hube B
DOI：
10.1164/ajrccm.164.supplement_2.2106066
发表时间：
2001-11-15
影响因子：
24.7
作者：
Fahy, JV
通讯作者：
Fahy, JV