3D printing of unique water-soluble polymer-based suppository shell for controlled drug release.
3D printing of unique water-soluble polymer-based suppository shell for controlled drug release.
复制标题
3D 打印独特的水溶性聚合物栓剂外壳，用于控制药物释放。
DOI：
10.1016/j.ijpharm.2019.118494
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Ozeki T.
中科院分区：
文献类型：
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作者：
Tagami T;Hayashi N;Sakai N;Ozeki T.
3D打印技术有望应用于个性化药物。模具制造是工业3D打印中的一种常用技术，用于生产具有复杂结构的物体，并可用于制药生产的新应用。当前研究的目的是使用熔融沉积建模型3D打印机制造由水溶性聚合物（聚乙烯醇）组成的独特栓剂壳模具，以便医院药剂师可以在未来的临床环境中制备量身定制的含有黄体酮（阴道模型药物）的栓剂制剂。制备在壳中具有孔的栓剂制剂。药物释放曲线与栓剂中的孔的位置（上、中、下）、孔的数量（0-2个孔）和孔的直径（0-5 mm）良好相关。然后制备由3D打印的多层壳组成的Matryoshka型栓剂制剂。药物释放曲线呈脉冲式释放，释放曲线反映了栓剂壳内外空间体积（1/1，1/3）和药物浓度（3/1，1/1）。我们的研究表明，3D打印机不仅可以生产独特和复杂的栓剂配方，还可以提供灵活性，并扩大定制药物开发的可能应用。
3D printing technology holds promise for application to personalized pharmaceuticals. Mold fabrication is a common technique in industrial 3D printing to produce objects with complex structures and could be used in new applications in pharmaceutical production. The aim of the current study is the fabrication of unique suppository shell molds composed of a water-soluble polymer (polyvinylalcohol) using a fused deposition modeling-type 3D printer so that hospital pharmacists can prepare tailored suppository formulations containing progesterone (a model drug for vaginal suppository formulations) in future clinical settings. Suppository formulations with holes in the shells were prepared. The drug release profiles related well to the positions of the holes (upper, middle, lower), the number of holes (0–2 holes), and the diameters of the holes (0–5 mm) in the suppositories. Matryoshka-type suppository formulations composed of 3D-printed multilayered shells were then prepared. The drug release profiles showed pulsed release, and the volumes of the inner/outer spaces in the suppository shells (1/1, 1/3) and the drug concentration (3/1, 1/1) were reflected in the observed drug release profiles. Our study indicates that a 3D printer can produce not only unique and complex suppository formulations, but also provides flexibility and expands possible applications for the development of tailored medicine.