Fatalities due to anaphylactic reactions to foods
Fatalities due to anaphylactic reactions to foods
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DOI：
10.1067/mai.2001.112031
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发表时间：
2001-01-01
影响因子：
14.2
通讯作者：
Sampson, HA
中科院分区：
文献类型：
--
作者：
Bock, SA;Muñoz-Furlong, A;Sampson, HA
对食物的致死性过敏反应仍在继续发生，更好的描述可能导致更好的预防。本报告的目的是记录正在发生的死亡并描述这些死亡。在食物过敏和过敏反应网络的协助下，我们分析了美国过敏、哮喘和免疫学学会建立的国家登记处报告的32例死亡病例，并从多个来源收集了足够的数据，包括结构化问卷，用于确定死亡原因和相关因素。32人可分为两组。第一组有足够的数据确定14例（67%）的病例中花生是主要食物，7例（33%）的病例中坚果是主要食物。在第二组中，6例（55%）可能因花生而死亡，3例（27%）可能因树坚果而死亡，另外2例可能因牛奶和鱼而死亡（各1例[9%]）。两性受到的影响是一样的；大多数受害者是青少年或年轻人，除1名受试者外，所有受试者在致命事件发生前都已知有食物过敏。在可获得数据的受试者中，除1名受试者外，所有受试者都已知有哮喘，而且这些人中的大多数在发生致命反应时都没有肾上腺素。易感人群因摄入致敏食物而死亡仍然是一个主要的健康问题。在本系列研究中，花生和树花生占死亡人数的90%以上。要阻止这些悲剧的发生，必须提高对专业人士、过敏人士和公众的教育水平。
Fatal anaphylactic reactions to foods are continuing to occur and better characterization might lead to better prevention, The objective of this report is to document the ongoing deaths and characterize these fatalities. We analyzed 32 fatal cases reported to a national registry, which was established by the American Academy of Allergy, Asthma, and Immunology, with the assistance of the Food Allergy and Anaphylaxis Network, and far which adequate data could be collected, Data were collected from multiple sources including a structured questionnaire, which was used to determine the cause of death and associated factors. The 32 individuals could be divided into 2 groups. Group 1 had sufficient data to identify peanut as the responsible food in 14 (67%) and tree nuts in 7 (33%) of cases. In group 2 subjects, 6 (55%) of the fatalities were probably due to peanut, 3 (27%) to tree nuts, and the other 2 cases were probably due to milk and fish (1 [9%] each). The sexes were equally affected; most victims were adolescents or young adults, and all but 1 subject were known to have food allergy before the fatal event In those subjects for whom data were available, all but 1 was known to have asthma, and most of these individuals did not have epinephrine available at the time of their fatal reaction. Fatalities due to ingestion of allergenic foods in susceptible individuals remain a major health problem In this series, peanuts and tree mts accounted for more than 90% of the fatalities. Improved education of the profession, allergic individuals, and the public will be necessary to stop these tragedies.