Comparison of the responses of fetal and adult cardiac muscle to hypoxia.
Comparison of the responses of fetal and adult cardiac muscle to hypoxia.
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胎儿和成人心肌对缺氧反应的比较。
DOI：
10.1152/ajplegacy.1973.224.6.1249
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发表时间：
1973
影响因子：
--
通讯作者：
Friedman Wf
中科院分区：
文献类型：
--
作者：
Su Jy;Friedman Wf
Su，JUDY Y Y.，和威廉F。弗里德曼。胎儿与成人心肌对缺氧反应的比较。Am. J. Physiol.224（6）：1249-1253. 1973.-比较了胎羊和成年羊心肌组织在选择性抑制有氧代谢和无氧代谢后的反应。缺氧或暴露于二硝基酚对成人右心房收缩频率的抑制作用明显大于胎儿右心房。胎儿右心房对碘乙酸抑制糖酵解的敏感性高于成人。胎儿和成人心室肌在缺氧或缺糖时产生张力的能力无差异。胎儿和成人的心房和心室心肌对缺氧和碘乙酸的联合作用比单独的干预更敏感。在没有葡萄糖的情况下，缺氧抑制成人心房和心室组织的程度比在葡萄糖存在下观察到的更大。相反，当胎儿心肌暴露于缺氧和葡萄糖剥夺的组合时，观察到继发性正性变时性和正性肌力反应，可被β-肾上腺素能阻断剂普萘洛尔（10+ M）阻断。结果表明，与成人心脏相比，胎儿心脏更依赖糖酵解而不是有氧代谢作为能量来源。与成人相比，胎儿心脏对葡萄糖和氧剥夺的组合的次级正性变时性和变力性反应与心脏儿茶酚胺的优先年龄依赖性释放和胎儿心肌对去甲肾上腺素的超敏感性是相容的。
Su, JUDY Y., AND WILLIAM F. FRIEDMAN. Comparison of the responses of fetal and adult cardiac muscle to hypoxia. Am. J. Physiol. 224 (6): 1249-1253. 1973.-The responses of cardiac tissue isolated from fetal and adult sheep were compared after selective inhibition of aerobic and anaerobic metabolism. The frequency of contraction of adult right atria was significantly more depressed by oxygen deprivation or exposure to dinitrophenol than the fetal atria. Fetal right atria were more sensitive to inhibition of glycolysis by iodoacetate than the adult. No differences were observed in the ability of fetal and adult ventricular myocardium to generate tension with either oxygen or glucose deprivation. Both fetal and adult atria1 and ventricular myocardium were more sensitive to the combination of oxygen deprivation and iodoacetate than either intervention alone. In the absence of glucose, oxygen deprivation depressed adult atria1 and ventricular tissue to a greater extent than observed in the presence of glucose In contrast, when fetal myocardium was exposed to the combination of oxygen and glucose deprivation, a secondary, positive chronotropic and inotropic response was observed that could be blocked by the beta-adrenergic blocking agent, propranolol (10+ M). The results suggest that the fetal heart is more dependent on glycolytic than aerobic metabolism as an energy source when compared to the adult heart. The secondary, positive chronotropic and inotropic response of fetal heart to the combination of glucose and oxygen deprivation is compatible with a preferential agedependent release of cardiac catecholamines and a supersensitivity of fetal myocardium to norepinephrine when compared to the adult.