EFFECT OF SEROTONIN ON GLYCOGEN METABOLISM IN ISOLATED RAT LIVER.
EFFECT OF SEROTONIN ON GLYCOGEN METABOLISM IN ISOLATED RAT LIVER.
复制标题
血清素对离体大鼠肝脏糖原代谢的影响。
DOI：
10.1172/jci104966
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发表时间：
1964
期刊：
影响因子：
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通讯作者：
N. J. Giarman
中科院分区：
文献类型：
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作者：
R. Levine;L. Pesch;G. Klatskin;N. J. Giarman
在无脊椎动物肝吸虫肝片吸虫中，有证据表明5-羟色胺（5-羟色胺）增加糖酵解（1，2），糖原分解（1）和磷酸化酶活性（3）。然而，以前的研究在哺乳动物肝脏，在体外和体内，已经产生了相互矛盾的结果，关于血清素对肝糖原含量，肝磷酸化酶，血糖的影响。一些研究者报告了一种高血糖作用，他们将其归因于肾上腺髓质释放肾上腺素（4，5）或肝脏中的直接糖原分解作用（6，7）。其他人发现血清素对血糖没有影响或产生低血糖（8-11）。为了研究5-羟色胺对肝糖原代谢的直接作用，我们采用了离体肝灌注技术。我们的研究结果表明，外源性或内源性5-羟色胺引起糖原分解，高血糖症，并刺激肝磷酸化酶活性在离体灌注大鼠肝脏。
In the invertebrate liver fluke, Fasciola hepatica, there is evidence that 5-hydroxytryptamine (serotonin) increases glycolysis (1, 2), glycogenolysis (1), and phosphorylase activity (3). However, previous studies in mammalian liver, in vitro and in vivo, have yielded conflicting results concerning the effect of serotonin on hepatic glycogen content, hepatic phosphorylase, and blood glucose. Some investigators have reported a hyperglycemic action that they have attributed either to liberation of epinephrine from the adrenal medulla (4, 5) or to a direct glycogenolytic effect in the liver (6, 7). Others have found that serotonin either has no effect on blood glucose or produces hypoglycemia (8-11). To investigate the direct action of serotonin on hepatic glycogen metabolism, we employed the technique of isolated liver perfusion. The results of our studies indicate that exogenous or endogenous serotonin causes glycogenolysis, hyperglycemia, and stimulation of hepatic phosphorylase activity in the isolated perfused rat liver.