Association Between ABO and Rh Blood Groups and SARS-CoV-2 Infection or Severe COVID-19 Illness A Population-Based Cohort Study
Association Between ABO and Rh Blood Groups and SARS-CoV-2 Infection or Severe COVID-19 Illness A Population-Based Cohort Study
复制标题
DOI：
10.7326/m20-4511
复制
发表时间：
2021-03-01
影响因子：
39.2
通讯作者：
Park, Alison L.
中科院分区：
文献类型：
--
作者：
Ray, Joel G.;Schull, Michael J.;Park, Alison L.
背景资料：ABO和Rh血型可能影响严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染的风险。目的：确定ABO和Rh血型是否与SARS-CoV-2感染和2019年严重冠状病毒病（COVID-19）疾病的风险相关。设计：基于人群的队列研究。设置：加拿大安大略。患者：所有在2007年1月至2019年12月期间进行ABO血型评估并随后在2020年1月15日至6月30日期间进行SARS-CoV-2检测的成人和儿童。测量：主要研究结果是通过病毒RNA聚合酶链反应检测确定的SARS-CoV-2感染。第二个结果是严重的COVID-19疾病或死亡。调整后的相对危险度（aRRs）和绝对危险度差异（ARDs）进行了人口统计学特征和合并症。结果：共纳入225 556人，平均年龄为54岁。O血型与A、AB和B血型合并的SARS-CoV-2感染的aRR为0.88（95% CI，0.84至0.92; ARD，-3.9/1000 [CI，-5.4至-2.5]）。Rh-血型对SARS-CoV-2感染具有保护作用（aRR，0.79 [CI，0.73至0.85]; ARD，-6.8/1000 [CI，-8.9至-4.7]），尤其是O型阴性（O-）患者（aRR，0.74 [CI，0.66至0.83]; ARD，-8.2/1000 [CI，-10.8至-5.3]）。与其他血型相比，与O型血型相关的严重COVID-19疾病或死亡的风险也较低（aRR，0.87 [CI，0.78至0.97]; ARD，-0.8/1000 [CI，-1.4至-0.2]）和Rh-vs Rh-阳性（aRR，0.82 [CI，0.68至0.96]; ARD，-1.1/1000 [CI，-2.0至-0.2]）。局限性：因严重COVID-19疾病迅速死亡的人可能没有进行SARS-CoV-2检测。O和Rh血型可能与SARS-CoV-2感染和严重COVID-19疾病的风险略低有关。
Background: The ABO and rhesus (Rh) blood groups may influence risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Objective: To determine whether ABO and Rh blood groups are associated with risk for SARS-CoV-2 infection and severe coronavirus disease 2019 (COVID-19) illness.Design: Population-based cohort study.Setting: Ontario, Canada. Patients: All adults and children who had ABO blood group assessed between January 2007 and December 2019 and who subsequently had SARS-CoV-2 testing between 15 January and 30 June 2020.Measurements: The main study outcome was SARS-CoV-2 infection, determined by viral RNA polymerase chain reaction testing. A second outcome was severe COVID-19 illness or death. Adjusted relative risks (aRRs) and absolute risk differences (ARDs) were adjusted for demographic characteristics and comorbidities.Results: A total of 225 556 persons were included, with a mean age of 54 years. The aRR of SARS-CoV-2 infection for O blood group versus A, AB, and B blood groups together was 0.88 (95% CI, 0.84 to 0.92; ARD, -3.9 per 1000 [CI, -5.4 to -2.5]). Rhesus-negative (Rh-) blood type was protective against SARS-CoV-2 infection (aRR, 0.79 [CI, 0.73 to 0.85]; ARD, -6.8 per 1000 [CI, -8.9 to -4.7]), especially for those who were O-negative (O-) (aRR, 0.74 [CI, 0.66 to 0.83]; ARD, -8.2 per 1000 [CI, -10.8 to -5.3]). There was also a lower risk for severe COVID-19 illness or death associated with type O blood group versus all others (aRR, 0.87 [CI, 0.78 to 0.97]; ARD, -0.8 per 1000 [CI, -1.4 to -0.2]) and with Rh- versus Rh-positive (aRR, 0.82 [CI, 0.68 to 0.96]; ARD, -1.1 per 1000 [CI, -2.0 to -0.2]).Limitation: Persons who rapidly died of severe COVID-19 illness may not have had SARS-CoV-2 testing.Conclusion: The O and Rh- blood groups may be associated with a slightly lower risk for SARS-CoV-2 infection and severe COVID-19 illness.