Differentiating cortical areas related to pain perception from stimulus identification: Temporal analysis of fMRI activity
Differentiating cortical areas related to pain perception from stimulus identification: Temporal analysis of fMRI activity
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DOI：
10.1152/jn.1999.81.6.2956
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发表时间：
1999-06-01
影响因子：
2.5
通讯作者：
Szeverenyi, NM
中科院分区：
文献类型：
--
作者：
Apkarian, AV;Darbar, A;Szeverenyi, NM
在最近的一项功能磁共振成像研究(FMRI)中，我们报告了在热痛任务中激活的皮质区域，并比较了这个皮质网络与在振动触觉任务和运动任务中激活的皮质区域之间的重叠程度。在本研究中，我们研究了所有三个任务的皮质激活的时间特性，并使用线性系统识别技术来从功能上区分在痛苦的热任务中识别的皮质区域。使用回波平面成像和表面线圈检测了10名惯用右手的受试者对侧大脑中三分之一的皮质活动。在另外8名受试者中，我们从心理生理角度考察了温度任务的时间特性。FMRI脉冲反应功能是根据振动触觉和运动任务中的皮质激活来估计的，并显示出与早期报道一致。给出fMRI脉冲响应函数和热刺激的时间进程以及相关的疼痛评级。生成了预测函数。在痛苦的热任务中，这些预测功能和皮质激活之间的相关性表明，顶叶皮质中信息处理的前后部逐渐转变。在这个区域内，前区的活动更能反映热刺激参数，而更后面的活动与痛觉的时间特性更好地相关。前连合水平的岛叶皮质与热刺激的相关性最强，Brodmann区5/7区与痛觉的相关性最强。讨论了这些观测结果的功能含义。
In a recent functional magnetic resonance imaging study (fMRI), we reported the cortical areas activated in a thermal painful task and compared the extent of overlap between this cortical network and those activated during a vibrotactile task and a motor task. in the present study we examine the temporal properties of the cortical activations for all three tasks and use linear systems identification techniques to functionally differentiate the cortical regions identified in the painful thermal task. Cortical activity was examined in the contralateral middle third of the brain of 10 right-handed subjects, using echo-planar imaging and a surface coil. in another eight subjects the temporal properties of the thermal task were examined psychophysically. The fMRI impulse response function was estimated from the cortical activations in the vibrotactile and motor tasks and shown to correspond to earlier reports. Given the fMRI impulse response function and the time courses for the thermal stimulus and the associated pain ratings. predictor functions were generated. The correlation between these predictor functions and cortical activations in the painful thermal task indicated a gradual transition of information processing anteroposteriorly in the parietal cortex. Within this region activity in the anterior areas more closely reflected thermal stimulus parameters, whereas activity more posteriorly was better related to the temporal properties of pain perception. insular cortex at the level of the anterior commissure was the region best related to the thermal stimulus, and Brodmann's area 5/7 was the region best related to the pain perception. The functional implications of these observations are discussed.