The effect of cadmium on the immune behaviour of guinea pigs with experimental ascariasis
The effect of cadmium on the immune behaviour of guinea pigs with experimental ascariasis
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DOI：
10.1017/s0022149x00015819
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发表时间：
1997-06-01
影响因子：
1.6
通讯作者：
Dvoroznakova, E
中科院分区：
文献类型：
--
作者：
Boroskova, Z;Dvoroznakova, E
研究了镉对豚鼠实验性蛔虫病免疫指标的亚慢性影响。口服氯化镉28天可显著抑制中毒动物淋巴器官T细胞和B细胞，抑制其腹膜巨噬细胞的代谢活性，实验第1天至第28天补体CH50和AH（50）水平较初始值有中度下降。在随后的亚慢性中毒豚鼠感染后，与感染的对照动物相比，细胞群和巨噬细胞代谢活性的值仍然受到明显抑制。而巨噬细胞的吞噬和代谢活性以及CH50和AH（50）水平在施用重金属和感染后的短时间内明显升高，但未达到感染组的水平。特异性循环抗体水平不受中毒影响。与对照组相比，中毒动物肺部迁移的蛔虫幼虫感染的平均强度增加了20%。结果证实了镉对所研究的细胞免疫和体液免疫的免疫参数的负面影响，以及对细菌感染后机体抗原刺激反应的损害。
The subchronic effect of cadmium on selected immunological parameters was studied in guinea pigs with experimental ascariasis. Cadmium chloride given orally for 28 days caused a considerable suppression of T- and B- cells in the lymphoid organs of intoxicated animals, of the metabolic activity of their peritoneal macrophages and a moderate decline in the level of complement CH50 and AH(50) from day 1 to day 28 of the experiment, in comparison with the initial value. After a subsequent infection of the subchronically intoxicated guinea pigs the values for both the cell populations and the macrophage metabolic activity remained considerably suppressed, compared with infected control animals. The phagocytic and metabolic activity of macrophages as well as the CH50 and AH(50) level, however, increased conspicuously for a short time after application of heavy metal and after infection but it did not reach the level of the infected group. The level of specific circulating antibodies was not affected by intoxication. Compared with the controls, the mean intensity of infection with Ascaris larvae migrating in the lungs of intoxicated animals increased by 20%. The results have established the negative effect of cadmium on the immunological parameters of the cellular immunity and humoral immunity studied and the impairment of the organism's response to the antigenic stimulus after an A. suum infection.