REFLEX APNEA FROM LARYNGEAL CHEMO-STIMULATION IN THE SLEEPING PREMATURE NEWBORN LAMB
REFLEX APNEA FROM LARYNGEAL CHEMO-STIMULATION IN THE SLEEPING PREMATURE NEWBORN LAMB
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DOI：
10.1203/00006450-198208000-00007
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
SUNDELL, H
中科院分区：
文献类型：
--
作者：
MARCHAL, F;CORKE, BC;SUNDELL, H
在安静和REM [快速眼动]睡眠和觉醒的早产新生羔羊的喉化学反射进行了研究。在30 s期间评价对5 s水灌注的反射刺激的反应，作为通气量、心率和血压的百分比变化。睡眠时呼吸暂停、高血压和心动过缓比清醒时更明显，而觉醒与刺激无关。这种反应在安静睡眠和快速眼动睡眠中是相似的。分别在24%和31%的测试中出现的觉醒导致的反应与清醒时的反应相当。通过测量平均吸气流量来评估呼吸驱动，与清醒状态相比，在两种睡眠状态下呼吸驱动均降低。在新生儿期的睡眠期间，对窒息的反应能力降低，这可能是由于动脉化学感受器的功能不成熟。这导致低的觉醒发生率和延迟终止由喉化学反射刺激引起的明显的刺激后呼吸暂停。
The laryngeal chemoreflex was studied during quiet and REM [rapid eye movement] sleep and wakefulness in premature newborn lambs. The response to reflex stimulation with a 5 s water infusion was evaluated during 30 s, as percent change in ventilation, heart rate and blood pressure. Apnea, hypertension and bradycardia were more pronounced during sleep than during wakefulness, when arousal was not associated with the stimulation. The response was similar during quiet and REM sleep. Arousal, which occurred in 24 and 31% of the tests, respectively, resulted in a response comparble to that seen during wakefulness. Respiratory drive was evaluated by measurement of the mean inspiratory flow and was decreased during both sleep states when compared to wakefulness. During sleep in the newborn period there is a decreased ability to respond to asphyxia possibly due to a functional immaturity of the arterial chemoreceptors. This results in a low incidence of arousal and a delayed termination of the pronounced poststimulus apnea resulting from laryngeal chemoreflex stimulation.