New directions in monoamine oxidase A and B selective inhibitors and substrates.
New directions in monoamine oxidase A and B selective inhibitors and substrates.
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DOI：
10.1016/0006-2952(91)90471-g
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发表时间：
1991-01
影响因子：
5.8
通讯作者：
M. Youdim;J. Finberg
中科院分区：
文献类型：
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作者：
M. Youdim;J. Finberg
单胺氧化酶（MAO）可能在中枢胺神经传递中发挥重要作用的第一个迹象始于观察到抗结核药物异proniazid给患者带来“减轻效应”，以及Zeller等人[1]证明其具有极强的MAO抑制作用。这一最初的观察被其他人证实，并导致了一项研究，该研究确定MAO抑制导致大脑中去甲肾上腺素和血清素[2]水平的增加。随后的发现为将MAO抑制剂引入情感障碍（抑郁症）的心理治疗提供了基础，并与氯丙嗪和利血平的发现一起打开了大门
BackgroundThe first indication that monoamine oxidase (MAO) might have an important function in central amine neurotransmission began with the observation that iproniazid, an antituberculous agent, brought about a “lightening effect” in patients, and the demonstration by Zeller et al.[l] of its highly potent MAO inhibitory action. This original observation was confirmed by others and led to the study which determined that MAO inhibition results in increased brain levels of noradrenaline and serotonin [2]. Subsequent findings provided the basis for the introduction of MAO inhibitors into psychotherapy of affective disorders (depression), which together with discoveries of chlorpromazine and reserpine opened