Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion.
Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion.
复制标题
由脂质体融合引起的卵磷脂酰胆碱脂质体中钼酸钙纳米颗粒的形成。
DOI：
10.1016/j.jcis.2018.07.007
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发表时间：
2018
影响因子：
9.9
通讯作者：
S.
中科院分区：
文献类型：
--
作者：
Yamasaki;S.;Kurita;S.;Ochiai;A.;Hashimoto;M.;Sueki;K. and Utsunomiya;S.
为了实现100mo (n, 2n)99Mo反应从100moo3高效生产99mtc，我们开发了一种合成纳米Mo粒子的新方案，其大小由脂质体的内部空间控制。钙和钼酸盐离子被包裹在约100 nm大小的脂质体中。然后将脂质体悬浮液混合并加热以促进膜融合。结果，不溶性camoo4纳米颗粒在脂质体内沉淀。SEM图像显示颗粒的中位数直径为168 nm，平均直径为169 ± 56 nm (n = 109)，颗粒呈粉状结构。然后检查了颗粒的形成过程。通过高分辨率TEM图像和阴性染色脂质体的TEM图像观察纳米camoo4的形成。室温下，脂质体的融合现象不明显。这些结果表明，在反应溶液的干燥过程中，脂质体可能发生融合聚集，从而在脂质体中形成camoo4纳米晶体。
In order to achieve the highly efficient99mTc production from100MoO3by the100Mo(n, 2n)99Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO4nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO4was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO4were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.