Chemoprophylaxis with erythromycin stearate or amoxycillin in patients with chronic bronchitis--effects on cellular and humoral immune functions.
Chemoprophylaxis with erythromycin stearate or amoxycillin in patients with chronic bronchitis--effects on cellular and humoral immune functions.
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慢性支气管炎患者用硬脂酸红霉素或阿莫西林进行化学预防——对细胞和体液免疫功能的影响。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
L. Olivier
中科院分区：
文献类型：
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作者：
Ras Gj;R. Anderson;H. Eftychis;U. Koch;A. Theron;H. Wyk;L. Olivier
26例年龄在27岁至71岁之间的慢性支气管炎患者分为对照组6例和两组10例，每组接受硬脂酸红霉素或阿莫西林1500 mg/d治疗2周，1000 mg/d治疗12周。化疗前、化疗后2周和14周分别进行免疫功能检查。临床评估和肺功能测试显示，在研究期间，任何一组都没有明显的变化。在对照组中，细胞和体液免疫功能未见变化。在接受阿莫西林治疗的组中，14天后观察到淋巴细胞对有丝分裂原植物血凝素的反应下降。在红霉素治疗组，14天观察到多态核白细胞（PMNL）活力和丝裂原诱导的转化增加，但这些增加没有统计学意义。该组3例患者治疗前PMNL迁移明显下降，改善明显。这些结果表明，无论是阿莫西林还是硬脂酸红霉素，化疗和化疗预防都不会损害宿主的免疫防御。
Twenty-six patients aged between 27 and 71 years with chronic bronchitis were divided into a control group of 6 and two groups of 10 patients each who received either erythromycin stearate or amoxycillin 1500 mg/d for 2 weeks and 1000 mg/d for 12 weeks thereafter. Immunological function tests were performed before starting chemotherapy and thereafter at 2 weeks and 14 weeks. Clinical evaluations and lung function tests showed no significant changes in any of the groups during the study period. In the control group no changes in cellular and humoral immune functions were noted. In the group receiving amoxycillin decreased responses of lymphocytes to the mitogen phytohaemagglutinin were observed after 14 days. In the erythromycin-treated group, increased polymorphonuclear leucocyte (PMNL) motility and mitogen-induced transformation were observed at 14 days but these increases were not statistically significant. In this group the markedly depressed PMNL migration found in 3 individuals before treatment improved considerably. These results indicate that chemotherapy and chemoprophylaxis with either amoxycillin or erythromycin stearate do not compromise the host immunodefences.